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Clinical trials and research at Centre Leon Berard

• 35Clinical trials
• 16Countries

Newest trials

All recruiting trials (35)

• Gastric Cancer Clinicobiological Cohort Study

  This study tests the tumor microenvironment in gastric and gastroesophageal junction cancers from patients who had surgery after standard neoadjuvant chemotherapy at a single center.

  Recruiting Centre Leon Berard · Lyon · NCT07787052

• Impact of Exercise on Tumor Immunity in NSCLC Patients Receiving Neoadjuvant Chemo-Immunotherapy

  A structured exercise program is being tested to see if it boosts immune cells in the tumor for patients with resectable NSCLC undergoing pre-surgery chemo-immunotherapy.

  Recruiting at 2 sites Centre Leon Berard · Lyon, Rhône and 1 other locations · NCT07786909

• Canut Junior: Testing Sensory Changes and Eating in Kids with Cancer

  This feasibility study tests whether we can measure taste, smell, saliva, and food preferences in children and teens undergoing cancer treatment to see if it’s doable in real-world care.

  Recruiting Centre Leon Berard · Lyon · NCT07632560

• How health and motivation change during the 13-week KHEOPS physical activity program for women treated for breast cancer

  This study will see how clinical symptoms and motivation change during a 13-week KHEOPS physical activity program for women with non-metastatic breast cancer.

  Recruiting Centre Leon Berard · Lyon · NCT07515326

• Increasing HPV vaccination among middle and high school students in Auvergne-Rhône-Alpes

  This project will try a school-based HPV prevention program to see if it increases vaccination rates among 11–17-year-old students in the Auvergne-Rhône-Alpes region.

  Recruiting Centre Leon Berard · Saint-Priest · NCT07414719

• How venetoclax blood levels relate to treatment response in acute myeloid leukemia

  This project will test how blood levels of venetoclax relate to treatment effects in adults with AML who are starting venetoclax plus azacitidine.

  Recruiting at 5 sites Centre Leon Berard · Bourgoin, France and 4 other locations · NCT07243483

• Tarlatamab plus temozolomide for DLL3-positive high-grade brain and other CNS tumors

  This trial tests whether adding the experimental immunotherapy tarlatamab to a fixed, low-dose temozolomide schedule helps adolescents and adults (≥12 years) with DLL3-positive recurrent or refractory high-grade brain and other CNS tumors.

  Recruiting at 8 sites Phase 1/2 Centre Leon Berard · Angers and 11 other locations · NCT07243470

• Preoperative magnetic clip versus wire localization for breast-conserving surgery in France.

  This project tests whether magnetic clips or traditional metal wires work better and cost less for women having breast-conserving surgery to locate a single, non-palpable breast cancer lesion.

  Recruiting at 6 sites Centre Leon Berard · Lyon and 6 other locations · NCT06906601

• Lifestyle advice for people with adenomas after a positive colorectal screening test

  This trial will try giving evidence-based diet and lifestyle advice to people in France who had a positive FIT and adenomas but no cancer to see if it improves their diet, activity, quality of life, and body measurements over one year.

  Recruiting Centre Leon Berard · Lyon, France · NCT06827366

• Treatment for head and neck cancer using tailored radiotherapy and ATRA

  This study is testing if a new combination of a cancer drug called ATRA with personalized radiotherapy can help people with certain types of head and neck cancer live longer and feel better.

  Recruiting at 8 sites Phase 3 Centre Leon Berard · Lyon, France and 7 other locations · NCT06706401

• Adjuvant radiation versus monitoring after surgery for high-risk cutaneous squamous cell carcinoma

  This compares adding adjuvant radiation after complete surgery to close monitoring to see if people with high-risk cutaneous squamous cell carcinoma stay free of cancer longer.

  Recruiting at 11 sites Phase 3 Centre Leon Berard · Le Puy-en-Velay, Auvergne-Rhône-Alpes and 27 other locations · NCT06692556

• Re-irradiation with curative intent guided by multicenter expert review and deformable dose fusion software

  This study tests whether a standardized, team-based review and dose-summation using deformable fusion software can change treatment plans for adults needing a second, potentially curative radiation course.

  Recruiting at 2 sites Centre Leon Berard · Angers and 9 other locations · NCT06668038

• Combining Durvalumab with Etoposide and Platinum for Lung Cancer Treatment

  This study is testing if combining a new immune therapy with chemotherapy can help people with advanced lung cancer feel better and live longer.

  Recruiting at 2 sites Phase 2 Centre Leon Berard · Aix-en-Provence and 30 other locations · NCT06393816

• Evaluating a software tool for nutritional management in gastric cancer patients

  This study is testing a new software tool to help people with stomach cancer manage their nutrition better to see if it can improve their recovery and quality of life.

  Recruiting Phase 2 Centre Leon Berard · Lyon · NCT06385691

• Combining two immunotherapy drugs for MSI-H/dMMR advanced stomach and gastroesophageal junction cancer

  This trial will try two immunotherapy drugs (balstilimab and botensilimab) as first treatment for adults with MSI‑H/dMMR, HER2‑negative advanced or metastatic stomach or gastroesophageal‑junction cancer whose tumors have PD‑L1 CPS ≥5, and will compare that to standard chemotherapy with nivolumab.

  Recruiting at 7 sites Phase 3 Centre Leon Berard · Brest and 6 other locations · NCT06346197

• Impact of the PASCA Program on Complications in Multiple Myeloma Patients Undergoing Stem Cell Transplant

  This study is testing if a special care program can help people with multiple myeloma have fewer complications during their stem cell transplant compared to standard care.

  Recruiting at 6 sites Centre Leon Berard · Épagny and 5 other locations · NCT05947136

• Comparing negative pressure dressing to standard dressing for healing after soft tissue sarcoma surgery

  This study is testing if a special type of dressing called negative pressure therapy can help people heal better after surgery for soft tissue sarcoma compared to regular dressings.

  Recruiting at 11 sites Centre Leon Berard · Nantes, Pays de Loire and 14 other locations · NCT05944913

• Multidisciplinary support for young cancer survivors

  This study is testing whether a special support program can help young cancer survivors aged 15 to 25 feel better and improve their quality of life after finishing treatment.

  Recruiting Centre Leon Berard · Lyon · NCT05858424

• Preventing second cancers with Dostarlimab treatment

  This study is testing if the drug Dostarlimab can help prevent second cancers in people who are at high risk after finishing treatment for their first cancer.

  Recruiting at 5 sites Phase 2 Centre Leon Berard · Caen and 4 other locations · NCT05855811

• Understanding the immune environment in gastroesophageal cancer

  This study looks at how the immune system reacts in patients with stomach and gastroesophageal junction cancer who are receiving chemotherapy to see if it can help improve their treatment outcomes.

  Recruiting Centre Leon Berard · Lyon · NCT05644431

• Physical activity program to reduce cancer-related fatigue in men with metastatic testicular cancer

  This study is testing whether a physical activity program can help men with metastatic testicular cancer feel less tired and improve their overall quality of life.

  Recruiting at 3 sites Centre Leon Berard · Angers and 11 other locations · NCT05588700

• De-escalation treatment for early-stage seminoma

  This study is testing whether giving less treatment after surgery for early-stage seminoma can still be effective while reducing side effects for patients.

  Recruiting at 12 sites Phase 2 Centre Leon Berard · Besançon and 14 other locations · NCT05529251

• Molecular screening for advanced pancreatic cancer patients

  This study is testing if analyzing tumor and blood samples from patients with advanced pancreatic cancer can help doctors choose the best personalized treatment options before they start their first round of therapy.

  Recruiting Centre Leon Berard · Lyon · NCT05380414

• Using cryotherapy to treat neurofibromas in patients with Neurofibromatosis Type 1

  This study is testing if using extreme cold to treat tough tumors can help people with Neurofibromatosis Type 1 feel better without needing surgery.

  Recruiting Centre Leon Berard · Lyon · NCT05199376

• Evaluating Imatinib Treatment After 10 Years for GIST Patients

  This study is testing whether stopping or continuing imatinib treatment helps people with advanced gastrointestinal stromal tumors who have been on the medication for at least 10 years.

  Recruiting at 6 sites Phase 2 Centre Leon Berard · Besançon and 12 other locations · NCT05009927

• Using regorafenib with supportive care for patients with high-grade bone sarcomas

  This study is testing if the drug regorafenib, along with supportive care, can help people aged 12 and older with high-grade bone sarcomas who haven't fully responded to standard treatment.

  Recruiting at 8 sites Phase 2 Centre Leon Berard · Besançon and 15 other locations · NCT04698785

• Understanding immune changes in breast and ovarian cancer patients

  This study looks at how the immune system changes in women with breast and ovarian cancer to find ways to make treatments work better.

  Recruiting Centre Leon Berard · Lyon, France · NCT04562623

• Evaluating targeted cancer treatments based on tumor characteristics in advanced tumors

  This study is testing if personalized cancer treatments based on the specific characteristics of a patient's advanced tumor can help them when standard treatments aren't working.

  Recruiting at 9 sites Phase 2 Centre Leon Berard · Angers and 12 other locations · NCT04116541

• Using Regorafenib to Maintain Treatment Benefits After Initial Therapy for Bone Sarcomas

  This study is testing if the drug regorafenib can help people with bone sarcomas stay cancer-free longer after their initial treatment.

  Recruiting at 12 sites Centre Leon Berard · Besançon and 15 other locations · NCT04055220

• Analysis of exocrine pancreatic tumors

  This study looks at data from patients with pancreatic tumors to see how the tumors' characteristics relate to their outcomes and help improve treatment options.

  Recruiting Centre Leon Berard · Lyon · NCT04011982

• Examining the role of microbiota and immune cells in colorectal tissue

  This study is trying to understand how the bacteria and immune cells in the colon affect the development of colorectal cancer in patients who are about to have surgery.

  Recruiting at 3 sites Centre Leon Berard · Lyon, Lyon and 2 other locations · NCT03841799

• Comparing treatment strategies for low grade endometrial stromal sarcoma

  This study is testing whether stopping or continuing a specific hormone therapy helps people with low grade endometrial stromal sarcoma live longer without their cancer getting worse.

  Recruiting at 21 sites Phase 2 Centre Leon Berard · Besançon and 21 other locations · NCT03624244

• Characterizing genetic profiles in advanced non-small cell lung cancer using liquid biopsies

  This study is testing whether a simple blood test can help find genetic changes in patients with advanced lung cancer to guide their treatment options.

  Recruiting Centre Leon Berard · Annecy and 7 other locations · NCT02511288

• Improving diagnosis and treatment for children with ependymoma

  This study is trying to improve how children with ependymoma are diagnosed and treated by organizing their care and testing new treatment strategies based on their specific needs.

  Recruiting at 38 sites Phase 2/3 Centre Leon Berard · Graz and 39 other locations · NCT02265770

• Personalized treatment for advanced solid tumors based on tumor genetics

  This study tests whether personalized treatments based on the genetic makeup of advanced solid tumors can help patients with stable disease feel better compared to standard therapies.

  Recruiting at 7 sites Phase 2 Centre Leon Berard · Bordeaux and 6 other locations · NCT02029001

Quick answers

How many clinical trials run by Centre Leon Berard are recruiting right now?

35, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in France (35 trials), Austria (1 trial), Belgium (1 trial), Czechia (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 9, Phase 3: 3, Phase 1/2: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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