Physical activity program to reduce cancer-related fatigue in men with metastatic testicular cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of a physical activity program on reducing long-term cancer-related fatigue in men diagnosed with metastatic testicular germ cell tumors. Participants will engage in a structured physical activity intervention, monitored through connected activity trackers, to assess improvements in fatigue and overall quality of life. The study also aims to explore the relationship between physical activity, gut microbiota composition, and the sequelae experienced by cancer survivors. By focusing on this specific patient population, the study seeks to fill a gap in existing research regarding the benefits of physical activity for testicular cancer survivors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men ≥18 years
* With a metastatic germ cell tumor histologically confirmed (seminoma and non-seminoma)
* Who have already undergone an orchidectomy (since the 16th december, this criteria was deleted).
* Having a first line of chemotherapy planned with BEP, EP or VIP
* Having a smartphone (i.e. to connect the activity tracker)
* PS \< or = 2
* Whose ability to practice an adapted physical activity (APA) has been certified by a medical certificate issued by the referring oncologist or the investigating physician
* Available and willing to participate in the study for the duration of the intervention and follow-up,
* Able to understand, read and write French,
* Affiliated with a social security scheme,
* Having dated and signed an informed consent.

Exclusion Criteria:

* Presence of symptomatic bone and/or brain metastases
* Central nervous system involvement with neurological deficits preventing walking
* History or coexistence of another primary cancer (apart from in situ cancer of any location and/or basal cell skin cancer and/or basal cell skin cancer and/or a cancer in complete remission for more than 3 years),
* Contraindication to physical activity (e.g. uncontrolled hypertension, uncontrolled heart disease) uncontrolled heart disease),
* Unable to be followed for medical, social, family, geographical or psychological reasons, during the entire study period,
* Deprived of liberty by judicial or administrative decision, or adults protected by law,
* Concurrent participation in another study in PA.

Where it's running

• Centre Leon Berard
  Lyon, France Recruiting
• Institut de Cancérologie de Lorraine
  Nancy, France Recruiting
• Institut Gustave Roussy
  Villejuif, France Recruiting
• Institut de Cancérologie de Lorraine
  Angers, France Not yet recruiting
• CHU Jean Minjoz
  Besançon, France Not yet recruiting
• Institut Bergonié
  Bordeaux, France Not yet recruiting

Study contacts

• Principal investigator: Aude Fléchon, MD — Centre Leon Berard
• Study coordinator: Carmen Dupuis, PhD
• Email: carmen.dupuis@lyon.unicancer.fr
• Phone: 0469856218

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• TASTY taste-steering for chemotherapy-related taste changes

  This trial tests whether an at-home 'taste steering' program helps adults on chemotherapy for metastatic triple-negative breast cancer, metastatic testicular cancer, or stage II–IV diffuse large B cell lymphoma enjoy food more.

  Recruiting at 6 sites University Medical Center Groningen · Amsterdam and 10 other locations · NCT07258563

• Gastric Cancer Clinicobiological Cohort Study

  This study tests the tumor microenvironment in gastric and gastroesophageal junction cancers from patients who had surgery after standard neoadjuvant chemotherapy at a single center.

  Recruiting Centre Leon Berard · Lyon · NCT07787052

• Impact of Exercise on Tumor Immunity in NSCLC Patients Receiving Neoadjuvant Chemo-Immunotherapy

  A structured exercise program is being tested to see if it boosts immune cells in the tumor for patients with resectable NSCLC undergoing pre-surgery chemo-immunotherapy.

  Recruiting at 2 sites Centre Leon Berard · Lyon, Rhône and 1 other locations · NCT07786909

• Canut Junior: Testing Sensory Changes and Eating in Kids with Cancer

  This feasibility study tests whether we can measure taste, smell, saliva, and food preferences in children and teens undergoing cancer treatment to see if it’s doable in real-world care.

  Recruiting Centre Leon Berard · Lyon · NCT07632560

• How health and motivation change during the 13-week KHEOPS physical activity program for women treated for breast cancer

  This study will see how clinical symptoms and motivation change during a 13-week KHEOPS physical activity program for women with non-metastatic breast cancer.

  Recruiting Centre Leon Berard · Lyon · NCT07515326

• Increasing HPV vaccination among middle and high school students in Auvergne-Rhône-Alpes

  This project will try a school-based HPV prevention program to see if it increases vaccination rates among 11–17-year-old students in the Auvergne-Rhône-Alpes region.

  Recruiting Centre Leon Berard · Saint-Priest · NCT07414719

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.