Gastric Cancer Clinicobiological Cohort Study

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinicobiological cohort collects tumor and lymph node tissue from adults with non-metastatic, resectable gastric or GEJ adenocarcinoma who have completed standard neoadjuvant chemotherapy. RNA sequencing and HyperIon analysis are used to characterize the tumor microenvironment, using samples obtained as part of routine care. The study aims to describe molecular and cellular features in relation to treatment response and surgical outcomes. Enrollment is limited to patients with available archival FFPE blocks and a confirmed post-therapy pathology response per TRG criteria. Participation is voluntary and linked to standard clinical management at Centre Léon Bérard.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients with histologically proven non-metastatic resectable gastric and gastroesophageal junction adenocarcinoma, Stage IB to III be treated with standard neoadjuvant chemotherapy
* Knwon response to neoadjuvant chemotherapy as per TRG criteria
* Surgery of primary tumor done at Centre Léon Bérard. Availability of archival FFPE tumor block from initial diagnosis with at least 20% of tumor cells and collected lymp nodes

Exclusion Criteria:

* Patient refusal to participate to this clinicobiological cohort

Where it's running

• Centre Léon Bérard
  Lyon, France Recruiting

Study contacts

• Study coordinator: Clelia Coutzac, MD,PhD
• Email: clelia.coutzac@lyon.unicancer.fr
• Phone: 0033478782828

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.