Understanding how HIV affects the brain using advanced cell models
Modeling CNS dynamics in HIV infection and cannabinoids with forebrain organoids
This study is looking at how HIV affects the brain and can cause thinking problems, using special 3D brain models made from human cells, to help find new ways to improve brain health for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10656388 on NIH RePORTER |
What this research studies
This research investigates the effects of HIV on the brain, particularly focusing on a condition known as HIV-Associated Neurocognitive Disorder (HAND). By using advanced 3D brain models created from human stem cells, researchers aim to study how HIV interacts with brain cells and how these interactions may lead to cognitive issues in HIV-positive individuals. The study will also explore the role of cannabinoids and other factors in modifying these interactions, providing insights into potential therapeutic approaches. Patients may benefit from a better understanding of how HIV affects brain function and the development of new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-positive individuals experiencing cognitive difficulties, particularly those with HAND.
Not a fit: Patients who are HIV-negative or do not have cognitive impairments related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive disorders in HIV-positive patients.
How similar studies have performed: Previous research has shown promise in using similar 3D models to study neurological diseases, indicating potential for success in this approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Jordan-Sciutto, Kelly L — University of Pennsylvania
- Study coordinator: Jordan-Sciutto, Kelly L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.