Testing new ways to help smokers quit by changing treatments

A clinical trial of adaptive treatment for early smoking cessation relapse

NIH-funded research Medical University of South Carolina · NIH-10875543

This study is looking at whether changing smoking cessation medications or trying e-cigarettes can help people who have had a hard time quitting smoking finally succeed, and you'll get support and a month’s supply of medication to help you set a quit date.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionMedical University of South Carolina NIH-funded
Lab location1 site (Charleston, United States)
Project IDNIH-10875543 on NIH RePORTER

What this research studies

This research investigates how to improve smoking cessation outcomes for individuals who have struggled to quit smoking. It will explore whether switching between different FDA-approved medications after a failed attempt is more effective than sticking with the same treatment. Additionally, the study will assess if transitioning to e-cigarettes after multiple unsuccessful attempts with medications can help smokers achieve abstinence. Participants will receive a 4-week supply of smoking cessation medication and support to set a quit date.

Who could benefit from this research

Good fit: Ideal candidates are daily smokers aged 21 and older who are willing to set a quit date and have previously attempted to quit using pharmacotherapy.

Not a fit: Patients who have never smoked or those who are not interested in quitting smoking may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide more effective strategies for smokers to quit and reduce their dependence on cigarettes.

How similar studies have performed: While there has been some research on smoking cessation methods, this adaptive treatment approach is relatively novel and has not been extensively tested.

Where this research is happening

Charleston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Centers for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.