Testing new ways to help smokers quit by changing treatments
Official title: A clinical trial of adaptive treatment for early smoking cessation relapse
Funded at Medical University of South Carolina · NIH-10875543 · Data updated 2026-11-12
This study is looking at whether changing smoking cessation medications or trying e-cigarettes can help people who have had a hard time quitting smoking finally succeed, and you'll get support and a month’s supply of medication to help you set a quit date.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $574,662 |
| NIH project number | 5R01CA284649-02 |
| Project ID | NIH-10875543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are daily smokers aged 21 and older who are willing to set a quit date and have previously attempted to quit using pharmacotherapy.
✕Less likely to help
Patients who have never smoked or those who are not interested in quitting smoking may not benefit from this research.
What this research studies
This research investigates how to improve smoking cessation outcomes for individuals who have struggled to quit smoking. It will explore whether switching between different FDA-approved medications after a failed attempt is more effective than sticking with the same treatment. Additionally, the study will assess if transitioning to e-cigarettes after multiple unsuccessful attempts with medications can help smokers achieve abstinence. Participants will receive a 4-week supply of smoking cessation medication and support to set a quit date.
Why it matters
Potential benefit: If successful, this research could provide more effective strategies for smokers to quit and reduce their dependence on cigarettes.
How similar studies have gone: While there has been some research on smoking cessation methods, this adaptive treatment approach is relatively novel and has not been extensively tested.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Smith, Tracy Taylor — Medical University of South Carolina
- Study coordinator: Smith, Tracy Taylor
Related research
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Adaptive treatment for early smoking relapse in adults
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Smoking cessation help for people with HIV in South Africa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.