Helping people quit smoking for good
Official title: A clinical trial of adaptive treatment for early smoking cessation relapse
Funded at Medical University of South Carolina · NIH-11121737 · Data updated 2026-11-12
This project helps daily smokers find the best way to quit cigarettes, especially if their first attempt isn't successful.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $604,095 |
| NIH project number | 5R01CA284649-03 |
| Project ID | NIH-11121737 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are daily smokers aged 21 or older in South Carolina and Alabama who are ready to set a quit date.
✕Less likely to help
Patients who are not daily smokers or are not located in South Carolina or Alabama would not be eligible for this particular project.
What this research studies
Many people try to quit smoking, but it can be tough, and often the first attempt doesn't stick. This project looks at different ways to help you quit if your first try with medication doesn't work out. We want to see if switching to a different medication or even trying e-cigarettes could be more helpful than trying the same thing again. The goal is to find a personalized approach that gives you the best chance to stop smoking for good.
Why it matters
Potential benefit: If successful, this project could provide clearer guidance on how to adjust smoking cessation treatments when initial attempts are unsuccessful, leading to higher success rates for patients.
How similar studies have gone: This project explores a novel adaptive treatment approach for smoking cessation, as few previous trials have specifically investigated the best path forward after initial treatment failure.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Smith, Tracy Taylor — Medical University of South Carolina
- Study coordinator: Smith, Tracy Taylor
Related research
Other NIH-funded projects on the same topics.
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Social stress and smoking: why disadvantaged young adults struggle to quit
This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.
-
Adaptive treatment for early smoking relapse in adults
This study tests different paths to help adults who smoke quit again after an early relapse, including trying a different quitting medicine or switching to a safer nicotine product.
-
How social stress affects young adults' ability to quit smoking
This study looks at how everyday stress from money and social situations makes it harder for young adults with limited resources to quit smoking and stay smoke-free, so we can better understand their challenges and help them succeed in quitting.
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Testing new ways to help smokers quit by changing treatments
This study is looking at whether changing smoking cessation medications or trying e-cigarettes can help people who have had a hard time quitting smoking finally succeed, and you'll get support and a month’s supply of medication to help you set a quit date.
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I-STOP: a mobile health program to help people with HIV quit smoking
A smartphone-based program designed to help people with HIV quit smoking in a sustainable, affordable way.
-
Smoking cessation help for people with HIV in South Africa
A program is being tested to help people living with HIV in South Africa quit smoking in ways that fit low-resource clinics and show good value.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.