Statin use after brain bleed MRI study in ICH patients (SATURN MRI) Ancillary Study
Official title: StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary Study
Funded at Beth Israel Deaconess Medical Center · NIH-11625632 · Data updated 2026-11-12
This project tests whether continuing or stopping statin therapy after an intracerebral hemorrhage affects brain changes seen on MRI and related health outcomes in people with lobar ICH.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $41,552 |
| NIH project number | 3U01NS120871-03S2 |
| Project ID | NIH-11625632 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with lobar intracerebral hemorrhage who are enrolled in the SATURN trial and are taking statins.
✕Less likely to help
Patients taking statins who do not show MRI-detected progression of small vessel disease or who do not experience clinical benefits may not gain from continued therapy based on MRI markers.
What this research studies
The SATURN MRI ancillary study will enroll patients who have had lobar intracerebral hemorrhage and are participating in the larger SATURN trial. Participants will have standardized brain MRI scans at baseline and 24 months to look for markers of small vessel disease, such as cerebral microbleeds and cortical superficial siderosis. The study aims to see if ongoing statin therapy changes the appearance or progression of these MRI findings compared with stopping statins, and whether baseline MRI features help predict who benefits from continued statin use. This is done within a pragmatic, multicenter, randomized framework with blinded outcome assessment. Results could guide future decisions about statin use after ICH for long-term brain health and safety.
Why it matters
Potential benefit: If successful, this study could clarify whether continuing statins after lobar ICH helps or harms brain health and overall outcomes, guiding safer long-term therapy.
How similar studies have gone: Previous observational data suggest potential vascular benefits of statins, but randomized MRI-focused data in this exact setting are limited, making this study novel yet build on existing statin literature.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
Related research
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SATURN MRI ancillary study: statins after intracerebral hemorrhage and brain MRI markers
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Statin use after brain bleed: SATURN MRI ancillary study
This project tests whether continuing statin medicines after a brain bleed (lobar intracerebral hemorrhage) affects new brain blood vessel findings and long-term health.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
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Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.