SATURN MRI ancillary study: statins after intracerebral hemorrhage and brain MRI markers
Official title: StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary Study
Funded at Beth Israel Deaconess Medical Center · NIH-11625633 · Data updated 2026-11-12
This study looks at what happens to brain MRI markers and health outcomes when people with a specific type of brain bleed continue or stop taking statins.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $68,553 |
| NIH project number | 3U01NS120871-03S3 |
| Project ID | NIH-11625633 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with lobar intracerebral hemorrhage who are taking statins and are enrolled in the SATURN trial.
✕Less likely to help
Individuals not receiving statins or those without lobar ICH or not part of SATURN-related procedures.
What this research studies
If you had a lobar intracerebral hemorrhage and are on a statin, this ancillary MRI study will follow you with brain scans at the start and after about two years to see how statin use affects small vessel disease markers like microbleeds. It is built on the SATURN trial framework and uses a pragmatic, open-label design with blinded outcome assessment to explore safety and potential benefits of continuing statins. The researchers will compare ongoing statin therapy versus discontinuation and examine correlations between MRI findings and future risk of bleeding or other health events. The goal is to help personalize decisions about statin therapy for people who have had a lobar ICH and are at risk for recurrence.
Why it matters
Potential benefit: If successful, findings could guide safer, more effective use of statins in people with lobar ICH and inform imaging-based risk stratification.
How similar studies have gone: This is a continuation of SATURN; prior data are limited and the ancillary MRI study aims to add novel imaging insights.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
Related research
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Statin use after brain bleed MRI study in ICH patients (SATURN MRI) Ancillary Study
This project tests whether continuing or stopping statin therapy after an intracerebral hemorrhage affects brain changes seen on MRI and related health outcomes in people with lobar ICH.
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Statin use after brain bleed: SATURN MRI ancillary study
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Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.