Statin use after brain bleed: SATURN MRI ancillary study
Official title: StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary Study
Funded at Beth Israel Deaconess Medical Center · NIH-11625628 · Data updated 2026-11-12
This project tests whether continuing statin medicines after a brain bleed (lobar intracerebral hemorrhage) affects new brain blood vessel findings and long-term health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $33,793 |
| NIH project number | 3U01NS120871-03S1 |
| Project ID | NIH-11625628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of lobar intracerebral hemorrhage who are on statins and enrolled in the SATURN framework may be eligible.
✕Less likely to help
Patients not on statins or without lobar ICH may not benefit from this ancillary MRI study.
What this research studies
If you have had a lobar intracerebral hemorrhage, this study will follow participants with a brain MRI at the start and again after about two years to look for small vessel disease markers. It is built on the SATURN trial, but adds MRI measurements to see if keeping or stopping statins changes brain imaging and health outcomes. The MRI results may help doctors personalize statin use for people with this condition in the future. The study is open-label but uses blinded assessment of MRI findings to keep results unbiased.
Why it matters
Potential benefit: If successful, results could guide safer statin use after lobar ICH and inform personalized treatment decisions.
How similar studies have gone: Previous large trials in ICH have focused on outcomes from statin use; this MRI-focused ancillary study is exploring brain imaging markers and is an initial, exploratory step rather than a proven approach.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
Related research
Other NIH-funded projects on the same topics.
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Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
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SATURN MRI ancillary study: statins after intracerebral hemorrhage and brain MRI markers
This study looks at what happens to brain MRI markers and health outcomes when people with a specific type of brain bleed continue or stop taking statins.
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Statin use after brain bleed MRI study in ICH patients (SATURN MRI) Ancillary Study
This project tests whether continuing or stopping statin therapy after an intracerebral hemorrhage affects brain changes seen on MRI and related health outcomes in people with lobar ICH.
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Maternal Postpartum Monitoring with a Wearable Sensor (MOMS)
A wearable system called MOMS will continuously monitor multiple physiological signals in pregnant people to detect postpartum hemorrhage earlier than standard vital signs.
-
Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
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Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.