Optimal timing to pause GLP-1 receptor therapy before pregnancy
Official title: Prior Glucagon-like Peptide-1 Receptor Agonist Therapy and Pregnancy, Postpartum, and Child Cardiovascular Outcomes: A Target Trial
Funded at Northwestern University · NIH-11413873 · Data updated 2026-11-12
This grant aims to figure out the best waiting period after stopping GLP-1 receptor medications to have a healthy pregnancy and baby.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 10, 2025 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $705,369 |
| NIH project number | 5R01HL180694-02 |
| Project ID | NIH-11413873 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women of reproductive age who have used long-acting GLP-1 receptor agonists and are planning pregnancy or are pregnant.
✕Less likely to help
No direct benefit for those not considering pregnancy or those who have never used GLP-1 therapies.
What this research studies
Women using GLP-1 receptor medicines for heart health and weight management may plan pregnancy after stopping treatment. The project will study how different stopping intervals affect pregnancy, delivery, and child health outcomes. Researchers will use observational data and prior trial results to identify timing that minimizes risks, with a focus on cardiovascular health and weight changes around pregnancy. The ultimate goal is to guide doctors and patients on safe planning for pregnancy after GLP-1 therapy.
Why it matters
Potential benefit: Could help women plan safer pregnancies and improve outcomes for mothers and babies after stopping GLP-1 therapies.
How similar studies have gone: Prior data show rapid changes in weight and cardiovascular health after stopping GLP-1 therapies, but timing guidance for pregnancy is not established.
Where this research is happening
-
Northwestern University
Chicago, United States Active
Researchers
- Principal investigator: Khan, Sadiya Sana — Northwestern University
- Study coordinator: Khan, Sadiya Sana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.