LA-MOM: Long-Acting HIV ART in Pregnancy and After Birth
Official title: LA-MOM: Long-Acting ART in Pregnancy and Postpartum- Maternal Outcomes and Measurements
Funded at University of Pennsylvania · NIH-11470920 · Data updated 2026-11-12
This study follows pregnant people with HIV who receive long-acting injectable HIV medicines to understand how the drugs behave in the body, how they reach the baby, and what patients experience during pregnancy and after birth.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 8, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $486,433 |
| NIH project number | 1R21HD123948-01 |
| Project ID | NIH-11470920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant individuals living with HIV who are receiving every-two-month CAB/RPV long-acting ART as part of standard care.
✕Less likely to help
Individuals not on long-acting ART or not pregnant would not directly benefit from this study.
What this research studies
Pregnant individuals with HIV who are on every-two-month long-acting ART will be followed through the second and third trimesters and into the postpartum period. The study will measure how the drugs circulate in the body and whether drug levels stay within effective ranges. It will also examine how the drugs transfer from mother to placenta at delivery and collect patient-reported experiences through surveys and interviews. The findings will help clinicians optimize dosing, improve safety, and support adherence during a critical period for both mother and infant.
Why it matters
Potential benefit: If successful, the study could inform dosing strategies and improve HIV management for pregnant people and their babies, reducing transmission risk and improving maternal and infant outcomes.
How similar studies have gone: Past research has shown pharmacokinetic data can guide dosing, but this study provides specific data during pregnancy and postpartum for two-month ART regimens.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Short, William R — University of Pennsylvania
- Study coordinator: Short, William R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.