New lab model of resilience for people with opioid use disorder
Official title: A Novel Human Laboratory Model of Resilience Among Individuals with Opioid Use Disorder
Funded at Johns Hopkins University · NIH-11364959 · Data updated 2026-11-12
A Johns Hopkins team will create a controlled lab model to study resilience in people with opioid use disorder while they are stabilized on morphine.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $190,317 |
| NIH project number | 5K08DA058057-03 |
| Project ID | NIH-11364959 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with DSM-5–confirmed opioid use disorder who can participate in an inpatient stay and tolerate stabilized morphine dosing.
✕Less likely to help
Individuals without OUD or those unable to participate in inpatient stabilization may not benefit from this study.
What this research studies
This project will recruit adults with DSM-5 diagnosed OUD and keep them on stable oral morphine during a 10-day inpatient stay to minimize withdrawal effects. Researchers will run resilience-focused lab tasks and measure how these relate to heroin-seeking and decision-making behaviors, using a randomized within-subjects design. They will also deeply phenotype participants’ psychological, cognitive, and affective traits to better understand resilience in this population. The aim is to establish convergent validity between lab measures of resilience and self-reported resilience under stress and non-stress conditions. The study will recruit 50 completers to achieve meaningful, shaped insights into resilience in OUD.
Why it matters
Potential benefit: If successful, this model could guide personalized approaches to support resilience and reduce relapse risk in people with OUD.
How similar studies have gone: Previous work shows that laboratory resilience measures can relate to real-world stress responses in diverse populations, but this specific OUD-focused resilience model is novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Martinez, Suky — Johns Hopkins University
- Study coordinator: Martinez, Suky
Related research
Other NIH-funded projects on the same topics.
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Multi-omics look at risk and resilience to opioid use disorder in veterans with chronic pain
This grant funds a mentored 5-year project to understand why some veterans with chronic pain are more likely to develop opioid use disorder and what factors help them stay resilient.
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Understanding Resilience in Opioid Use Disorder
This project explores how personal strengths, or resilience, might help people with opioid use disorder manage cravings and make healthy choices.
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Understanding resilience in people with opioid use disorder
This study is looking for people with opioid use disorder to stay in a safe setting for 10 days, where they’ll take oral morphine and help researchers learn more about how being resilient can influence their choices and behaviors, with the hope of finding better ways to treat this condition.
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A tiny, targeted drug approach is being developed to help people with opioid use disorder by rewriting the epigenetic signals in the brain to reduce cravings and relapse risk.
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Increasing Access to Medications for Opioid Use Disorder for Unhoused Montanans
This project helps unhoused people in Montana get life-saving medicines for opioid use disorder through clinics connected to syringe service programs, a nurse-led MOUD model, and peer support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.