Understanding resilience in people with opioid use disorder
Official title: A Novel Human Laboratory Model of Resilience Among Individuals with Opioid Use Disorder
Funded at Johns Hopkins University · NIH-10808410 · Data updated 2026-11-12
This study is looking for people with opioid use disorder to stay in a safe setting for 10 days, where they’ll take oral morphine and help researchers learn more about how being resilient can influence their choices and behaviors, with the hope of finding better ways to treat this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $196,914 |
| NIH project number | 1K08DA058057-01A1 |
| Project ID | NIH-10808410 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who meet the DSM-5 criteria for opioid use disorder.
✕Less likely to help
Patients who do not have opioid use disorder or those who are not willing to participate in an inpatient setting may not benefit from this research.
What this research studies
This research aims to develop a laboratory model to study resilience among individuals with opioid use disorder (OUD). Participants who meet the criteria for OUD will be stabilized on oral morphine during a 10-day inpatient stay, allowing researchers to examine their behaviors related to resilience in a controlled environment. The study will utilize various psychological and cognitive assessments to better understand how resilience affects decision-making and heroin-seeking behaviors. By focusing on resilience, the research seeks to uncover new insights that could lead to improved treatment strategies for OUD.
Why it matters
Potential benefit: If successful, this research could lead to enhanced treatment approaches that leverage resilience to improve outcomes for individuals with opioid use disorder.
How similar studies have gone: While resilience has been studied in various contexts, this specific laboratory model for opioid use disorder is a novel approach that has not been extensively tested.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Martinez, Suky — Johns Hopkins University
- Study coordinator: Martinez, Suky
Related research
Other NIH-funded projects on the same topics.
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New lab model of resilience for people with opioid use disorder
A Johns Hopkins team will create a controlled lab model to study resilience in people with opioid use disorder while they are stabilized on morphine.
-
Multi-omics look at risk and resilience to opioid use disorder in veterans with chronic pain
This grant funds a mentored 5-year project to understand why some veterans with chronic pain are more likely to develop opioid use disorder and what factors help them stay resilient.
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Understanding Resilience in Opioid Use Disorder
This project explores how personal strengths, or resilience, might help people with opioid use disorder manage cravings and make healthy choices.
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Systems analysis to improve opioid use disorder care after jail release (SAIA-MOUD)
A program to help people with opioid use disorder get better, faster, and safer care after they leave jail.
-
Precise epigenetic drugs for opioid addiction
A tiny, targeted drug approach is being developed to help people with opioid use disorder by rewriting the epigenetic signals in the brain to reduce cravings and relapse risk.
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Increasing Access to Medications for Opioid Use Disorder for Unhoused Montanans
This project helps unhoused people in Montana get life-saving medicines for opioid use disorder through clinics connected to syringe service programs, a nurse-led MOUD model, and peer support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.