Understanding Resilience in Opioid Use Disorder
Official title: A Novel Human Laboratory Model of Resilience Among Individuals with Opioid Use Disorder
Funded at Johns Hopkins University · NIH-11118814 · Data updated 2026-11-12
This project explores how personal strengths, or resilience, might help people with opioid use disorder manage cravings and make healthy choices.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $191,683 |
| NIH project number | 5K08DA058057-02 |
| Project ID | NIH-11118814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals who have been diagnosed with opioid use disorder and are willing to participate in a 10-day inpatient program may be ideal candidates.
✕Less likely to help
Patients seeking immediate treatment for opioid use disorder may not directly benefit from participating in this foundational research.
What this research studies
We are looking for ways to understand why some people with opioid use disorder are better able to cope with challenges and avoid relapse. This project brings together 50 individuals with opioid use disorder for a 10-day inpatient stay, where they will receive stable medication. During this time, we will use special tasks and tests to measure their resilience, how they make decisions, and their responses to stress. Our goal is to see if these resilience measures connect to behaviors like drug-seeking.
Why it matters
Potential benefit: If successful, this work could help us better understand the factors that protect individuals from relapse and inform the development of new, personalized treatments for opioid use disorder.
How similar studies have gone: While the concept of resilience in addiction is recognized, this project aims to develop a novel laboratory model to objectively measure it.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Martinez, Suky — Johns Hopkins University
- Study coordinator: Martinez, Suky
Related research
Other NIH-funded projects on the same topics.
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New lab model of resilience for people with opioid use disorder
A Johns Hopkins team will create a controlled lab model to study resilience in people with opioid use disorder while they are stabilized on morphine.
-
Multi-omics look at risk and resilience to opioid use disorder in veterans with chronic pain
This grant funds a mentored 5-year project to understand why some veterans with chronic pain are more likely to develop opioid use disorder and what factors help them stay resilient.
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Understanding resilience in people with opioid use disorder
This study is looking for people with opioid use disorder to stay in a safe setting for 10 days, where they’ll take oral morphine and help researchers learn more about how being resilient can influence their choices and behaviors, with the hope of finding better ways to treat this condition.
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Systems analysis to improve opioid use disorder care after jail release (SAIA-MOUD)
A program to help people with opioid use disorder get better, faster, and safer care after they leave jail.
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Precise epigenetic drugs for opioid addiction
A tiny, targeted drug approach is being developed to help people with opioid use disorder by rewriting the epigenetic signals in the brain to reduce cravings and relapse risk.
-
Increasing Access to Medications for Opioid Use Disorder for Unhoused Montanans
This project helps unhoused people in Montana get life-saving medicines for opioid use disorder through clinics connected to syringe service programs, a nurse-led MOUD model, and peer support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.