Multi-omics look at risk and resilience to opioid use disorder in veterans with chronic pain
Official title: A Multi-Omics Investigation of Risk and Resilience for Opioid Use Disorder Among Chronic Pain Patients
Funded at Philadelphia VA Medical Center · NIH-11293772 · Data updated 2026-11-12
This grant funds a mentored 5-year project to understand why some veterans with chronic pain are more likely to develop opioid use disorder and what factors help them stay resilient.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Philadelphia VA Medical Center NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| NIH project number | 1IK2RD001004-01 |
| Project ID | NIH-11293772 on NIH RePORTER |
Who could benefit from this research
✓Could help
Veterans with chronic pain who are at risk for or have a history of opioid use or exposure, and who consent to provide multi-omics data and clinical information.
✕Less likely to help
Patients without chronic pain or without exposure to opioids may not directly benefit from this study.
What this research studies
This project will follow a mentor-guided plan over five years to collect and analyze genomic, epigenetic, transcriptomic, and proteomic data from veterans with chronic pain to identify factors that increase risk or confer resilience to OUD. It uses network-based machine learning to integrate multiple omics layers and link them to clinical outcomes and pain management pathways. The goal is to inform personalized prevention and treatment strategies for veterans at risk, improving how chronic pain and OUD are addressed in the VA system. Researchers will train in translational, precision medicine approaches to tailor care for veterans affected by both chronic pain and opioid use risk.
Why it matters
Potential benefit: If successful, the research could lead to precision prevention and tailored treatments that reduce opioid misuse and improve pain management for veterans.
How similar studies have gone: Prior multi-omics studies have shown promise in identifying risk pathways for addiction, but this specific focus on resilience in veterans with chronic pain is novel.
Where this research is happening
-
Philadelphia VA Medical Center
Philadelphia, United States Active
Researchers
- Principal investigator: Davis, Christal N — Philadelphia VA Medical Center
- Study coordinator: Davis, Christal N
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.