Sponsor or institution
Clinical trials and research at Pennsylvania State University, the
As of November 12, 2026, Find a Trial lists 373 NIH-funded research projects at this institution, with $188.0 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 373NIH research projects
NIH-funded research (newest 40 of 373)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Population Research Institute: Understanding how communities, movement, and social factors shape health across ages
A Pennsylvania State University research center is studying how where people live, move, and participate in families affects health and well‑being from childhood through adulthood.
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Integrated data platform for infectious disease research using scalable public infrastructure
A large NIH grant funds a platform that makes infectious-disease data easier to access, combine, and analyze using powerful public infrastructure so researchers can work faster and more collaboratively.
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READI-SET-GO: Improving Delirium Screening for Hospitalized Older Adults
A hospital-based program tests how well routine nurse delirium screening using UB-CAM works when integrated into the electronic health record to improve outcomes for older patients.
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Healthy Brain and Child Development: a big study following kids from birth through age 10
A large, nationwide study will follow 7,200 mothers and their babies to map how early life experiences shape brain growth and development.
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How sex differences affect the rewarding feel of aggression in the brain
This grant explores why aggressive experiences feel more rewarding in females and how specific brain circuits and chemical signals shape this in both sexes.
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How parents' emotions shape young children's anxiety
This project explores how parents' moment-by-moment emotions and bodily signals shape anxiety in children from infancy through age 11.
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How parents' moment-to-moment emotions shape anxiety in young children
This project looks at how parents' real-time emotions and biological responses relate to anxiety in children from infancy through middle childhood.
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How speech and swallowing work in people with Down syndrome
Researchers will look at how differences in the mouth, throat, and brain affect speech clarity and safe swallowing in children and adults with Down syndrome.
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How HSV-1 Change Over Time in Skin Cells
A study exploring how herpes simplex virus 1 evolves in skin cells to understand drug resistance and why infections recur.
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Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
A research project is creating better computer models and animal studies to help remove clots more safely and effectively in people who have an acute ischemic stroke.
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Understanding how ghrelin receptor signaling works to improve medicines
Researchers are studying how ghrelin receptor signaling can be directed for safer, more effective drugs by exploring how this receptor communicates inside cells.
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Role of liquid-liquid phase separation in malaria parasite gene control
This project looks at how a natural cellular process in the malaria parasite might control which genes are turned on, with the aim of finding new ways to fight malaria.
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Fine mapping of chromosome 18 CNVs linked to birth defects and autism features
A study to map chromosome 18 copy-number changes and connect them with physical birth defects and autistic traits in children.
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PROGRESS: preventing overweight in early childhood for rural, low‑income families
A program in rural, low‑income communities will test a strengthened parenting approach to help infants grow healthily and reduce future risk of overweight and type 2 diabetes.
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Infant diet questions that are quick, accurate, and easy to use
A small study will test three simple, baby-friendly ways to measure what infants eat so researchers can run better nutrition trials.
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3D aging human lung model to study how aging affects epithelial repair
A human-derived, 3D lung model built from stem cells will be aged in the lab to understand why the lung’s repair system slows down as we get older.
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Understanding how a new gene therapy could steer cancer evolution and help fight tumors
A research project is exploring a novel gene therapy that aims to steer cancer cells to become vulnerable and then be eliminated.
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Live-cell imaging of how gene bursts are controlled in 3D genome
This grant studies how gene-regulating enhancers and transcription machinery form in 3D inside living cells to control gene bursts, using mouse stem cells and development models.
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Biosensor-based selection of tumor-attacking immune cells
A new approach aims to quickly pick and grow the patient’s own tumor-fighting immune cells to treat cancer.
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Role of inflammatory signals in stress erythropoiesis
This project looks at how inflammation changes the way the body makes red blood cells during stress and anemia, to understand why steady production drops and stress pathways kick in.
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Democratization of data analysis in life sciences using Galaxy
A widely used open-source platform, Galaxy, is being enhanced to make advanced data analysis easier and more shareable for life-science researchers everywhere.
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Wastewater-based Genomic Surveillance for Foodborne Pathogens
A team will keep sequencing foodborne pathogens and build easy-to-use bioinformatic tools to track outbreaks using wastewater data.
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Reducing Lung Cancer Risk for Appalachian Women with Community-Driven Help
A community-informed program aims to lower lung cancer risk among Appalachian women by testing a behavior-focused intervention tailored to local social and environmental contexts.
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Who gets sent from the emergency room and where, including people with HIV/AIDS
This work compares how emergency room transfer timing and destinations differ for people, especially those with HIV/AIDS, low income, or from racial and ethnic minority groups.
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How the speed of making proteins affects their shape, mRNA stability, and cell behavior
Aims to understand how tiny changes in how quickly cells translate genetic code affect protein function, mRNA decay, and cell behavior in cancers.
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New statistical methods and software to study microbiome data
Aims to create user-friendly math tools and software to better analyze microbiome data from human health research.
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Phase-changing ultrasound contrast agents to image immune cells in deep tissue
A new ultrasound contrast agent helps doctors watch how engineered immune cells move and work in deep tumor tissue, so treatments can be tailored.
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Brief parent guide to reduce college students’ drinking and cannabis use
A short, parent-focused program helps college students cut back on drinking and cannabis use.
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Experimental study to improve use of research for protecting children
A nationwide study tests a theory-based approach to help decision-makers use scientific evidence to prevent child abuse and neglect.
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Patterns of somatic mutations in long-lived bats and what it means for aging
Researchers will study how somatic mutations accumulate in various bat species to understand aging and longevity and what this could mean for human aging in the future.
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Population genetics methods to understand how complex traits evolve
This grant supports work to better understand how our genes shape complex traits by studying human and other genomes with advanced population genetics tools.
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Helping rebuilt tissue grow organized blood vessels
This work develops ways to help people needing reconstructive surgery grow organized, functioning blood vessels in repaired tissues so grafts heal faster and more reliably.
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A portable photoacoustic device to help diagnose vascular diseases
A small, battery-powered imaging tool uses light and sound to help detect blood vessel problems at the point of care without harming patients.
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How early chemical exposure and long-term stress may affect thinking skills
This study looks at whether exposure to certain flame retardants during development plus chronic stress in adulthood can worsen thinking, memory, and decision-making in adults.
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Left posterior parietal brain stimulation to boost motor learning
A study tests whether non-invasive brain stimulation to the left back part of the brain can help people learn new movements faster and transfer skills between limbs.
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Physical-plasma catheter for heart infection treatment
A device that uses plasma to help treat infective endocarditis by targeting bacteria on heart tissue and prosthetic devices.
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NIH Open Measures Network: better brain health measures for Alzheimer's prevention trials
A national initiative to create open, flexible tools that measure cognitive change in people at risk for Alzheimer's and related dementias to improve prevention research.
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Charting how a mother’s depression affects a child’s positive feelings to predict early signs of anxiety or depression
This project follows young children of mothers with depression to see how early changes in reward processing relate to later internalizing symptoms.
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Ultrasound-controlled coating to release antibiotics from implanted devices
A new ultrasound-triggered coating on implanted devices can release antibiotics directly at the site to prevent or treat device-related infections.
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Understanding how bacterial lipoproteins in harmful Firmicutes change shape
This NIH project studies how important bacteria like Bacillus species modify their surface lipoproteins, which can affect how the body senses and fights infections.
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