Understanding kidney injury and disease using advanced imaging techniques
Official title: Spatial Elucidation of Human Acute Kidney Injury and Chronic Kidney Disease using Imaging Mass Cytometry
Funded at Yale University · NIH-10892126 · Data updated 2026-11-12
This study is looking at how kidney injuries and diseases affect your kidneys by examining tiny samples from patients who choose to join, using a special imaging technique to create detailed maps of kidney cells, which will help us better understand these conditions and find better treatments for everyone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $345,599 |
| NIH project number | 5U01DK133768-03 |
| Project ID | NIH-10892126 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients experiencing acute kidney injury who are willing to undergo kidney biopsies.
✕Less likely to help
Patients with stable chronic kidney disease or those who are not experiencing acute kidney injury may not benefit from this research.
What this research studies
This research investigates acute kidney injury (AKI) and chronic kidney disease (CKD) by analyzing kidney biopsies from patients who agree to participate. Using a technique called Imaging Mass Cytometry, the study aims to create detailed cellular maps of kidney tissues, identifying various cell types and their states during injury and repair. This approach combines advanced imaging with other data types to enhance our understanding of kidney diseases and improve treatment options. Patients who participate will contribute to a significant advancement in knowledge about human kidney conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for patients suffering from acute kidney injury and chronic kidney disease.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to understand kidney diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Kakade, Vijayakumar Raghurama Rao — Yale University
- Study coordinator: Kakade, Vijayakumar Raghurama Rao
Related research
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-
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-
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Mapping Kidney Damage in Acute and Chronic Kidney Disease
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-
Investigating kidney injury in children with chronic kidney disease
This study is looking at how to help kids with chronic kidney disease avoid sudden kidney problems and stay healthy by finding out what factors can be changed and how these issues affect their kidneys over time.
-
Investigating how heme affects kidney health in older adults
This study is looking at how certain old cells in the kidneys can cause problems in older adults with kidney issues, and it’s exploring whether a substance called heme might be making things worse; the goal is to find new ways to help improve kidney health in people aged 65 and older.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.