How sleep problems affect smoking relapse and how therapy can help

Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse: An RCT of CBT for Insomnia in Adults who Smoke

NIH-funded research Yale University · NIH-10985196

This study is looking at how better sleep can help adults who smoke stay smoke-free, and it will explore if a special therapy for sleep problems can improve mood and self-control while using brain scans to see how these changes happen.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionYale University NIH-funded
Lab location1 site (New Haven, United States)
Project IDNIH-10985196 on NIH RePORTER

What this research studies

This research investigates the connection between poor sleep and smoking relapse in adults. It focuses on how cognitive behavioral therapy for insomnia (CBT-I) can help improve mood, enhance self-control, and support smoking cessation. By using brain imaging techniques, the study aims to identify the neural mechanisms involved in these changes. Participants will be adults who smoke and are seeking treatment for their insomnia, allowing them to potentially benefit from this therapeutic approach.

Who could benefit from this research

Good fit: Ideal candidates are adults over 21 years old who smoke and experience insomnia.

Not a fit: Patients who do not smoke or do not have sleep problems may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved therapies for smoking cessation by addressing sleep issues.

How similar studies have performed: Previous research has shown promising results for CBT-I in improving sleep and reducing smoking relapse, suggesting this approach may be effective.

Where this research is happening

New Haven, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.