How sleep problems affect smoking relapse and how therapy can help
Official title: Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse: An RCT of CBT for Insomnia in Adults who Smoke
Funded at Yale University · NIH-10985196 · Data updated 2026-11-12
This study is looking at how better sleep can help adults who smoke stay smoke-free, and it will explore if a special therapy for sleep problems can improve mood and self-control while using brain scans to see how these changes happen.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $468,440 |
| NIH project number | 1R01DA061285-01 |
| Project ID | NIH-10985196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults over 21 years old who smoke and experience insomnia.
✕Less likely to help
Patients who do not smoke or do not have sleep problems may not benefit from this research.
What this research studies
This research investigates the connection between poor sleep and smoking relapse in adults. It focuses on how cognitive behavioral therapy for insomnia (CBT-I) can help improve mood, enhance self-control, and support smoking cessation. By using brain imaging techniques, the study aims to identify the neural mechanisms involved in these changes. Participants will be adults who smoke and are seeking treatment for their insomnia, allowing them to potentially benefit from this therapeutic approach.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for smoking cessation by addressing sleep issues.
How similar studies have gone: Previous research has shown promising results for CBT-I in improving sleep and reducing smoking relapse, suggesting this approach may be effective.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Li, Chiang-Shan Ray — Yale University
- Study coordinator: Li, Chiang-Shan Ray
Related research
Other NIH-funded projects on the same topics.
-
CBT for Insomnia to Help Adults Who Smoke Quit and Sleep Better
A sleep-focused therapy is tested to help adults who smoke sleep better, feel less negative, and improve their ability to quit smoking.
-
Improving Sleep to Help People Stop Smoking
This project explores how improving sleep with therapy might help people who smoke quit by boosting their mood and self-control.
-
Social stress and smoking: why disadvantaged young adults struggle to quit
This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.
-
Promoting Breastfeeding to Prevent Postpartum Smoking Relapse
A trial tests whether encouraging new mothers to breastfeed helps prevent them from starting to smoke again after giving birth.
-
Adaptive treatment for early smoking relapse in adults
This study tests different paths to help adults who smoke quit again after an early relapse, including trying a different quitting medicine or switching to a safer nicotine product.
-
Online Helpers training to reduce smoking relapse by strengthening your support network
An online program that teaches recent quitters to help friends or family stop smoking so their social circle becomes more supportive and they are less likely to relapse.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.