Thalamic Coordinated Reset Deep Brain Stimulation for Essential Tremor

Who could benefit from this research

What this research studies

This project tests a novel deep brain stimulation pattern called coordinated reset (CR) in the ventral intermediate nucleus (VIM) of the thalamus to reduce tremor in people with essential tremor. By delivering stimulation across multiple contacts with lower current, CR aims to lessen side effects and create lasting benefit after stopping stimulation. The study builds on evidence from Parkinson’s disease suggesting CR can counteract abnormal brain synchronization with fewer adverse effects. Participants would undergo implantation and follow-up to assess tremor changes, safety, and device performance. Results could lead to a less burdensome DBS option for ET patients who experience side effects or habituation with traditional stimulation.

Why it matters

Where this research is happening

• University of Minnesota
  Minneapolis, United States Active

Researchers

• Principal investigator: Wang, Jing — University of Minnesota
• Study coordinator: Wang, Jing

Related research

Other NIH-funded projects on the same topics.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.