Inflammation, High Blood Pressure, and Mom’s Long-Term Well-Being During Pregnancy
Official title: Project I: Inflammation, HTN, and Long-term Effects on Maternal Well Being
Funded at University of Mississippi Med Ctr · NIH-11397751 · Data updated 2026-11-12
This project looks at how immune changes during pregnancy-related high blood pressure may affect a mother’s brain health and mood, and how it could influence babies after birth.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | August 15, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $214,059 |
| NIH project number | 5U54HL170290-02 |
| Project ID | NIH-11397751 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant individuals with hypertension disorders (such as preeclampsia) and their offspring, from early pregnancy through postpartum.
✕Less likely to help
Individuals without hypertensive disorders during pregnancy or those outside the study’s follow-up period may not benefit.
What this research studies
If this research succeeds, it could help explain why some women with preeclampsia have anxiety, depression, or cognitive changes during and after pregnancy. The study will examine immune cells and autoantibodies in pregnant people with hypertensive disorders and how these relate to brain blood flow and the blood-brain barrier. It will also explore early child development in babies born to these mothers. The research combines maternal blood tests, imaging and measures of mood and cognition, and follows outcomes into the postpartum period.
Why it matters
Potential benefit: Understanding these links could lead to better monitoring and interventions to protect mothers’ mental health and children’s development.
How similar studies have gone: Animal studies and human observational data suggest immune factors and AT1 receptor antibodies are linked to hypertension and brain effects in pregnancy; this study seeks to translate those findings.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Wallace, Kedra L. — University of Mississippi Med Ctr
- Study coordinator: Wallace, Kedra L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.