Understanding the causes of excess acid in kidney stones
Official title: Origin of Excess Acid in Uric Acid Urolithiasis
Funded at Ut Southwestern Medical Center · NIH-10696033 · Data updated 2026-11-12
This study is looking into how gut bacteria and liver health might cause uric acid kidney stones, which are becoming more common, especially in people with obesity and diabetes, to help find better treatments for those who suffer from them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 5, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $449,722 |
| NIH project number | 5R01DK115703-05 |
| Project ID | NIH-10696033 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of uric acid kidney stones, particularly those who are obese or have metabolic syndrome.
✕Less likely to help
Patients who do not have a history of kidney stones or those with stones caused by other factors may not benefit from this research.
What this research studies
This research investigates the origins of uric acid kidney stones, which are becoming more common alongside rising rates of obesity and diabetes. It explores how the gut microbiota and liver function contribute to excessive acid production that leads to these stones. By conducting both animal and human studies, the research aims to identify the relationship between gut bacteria and kidney stone formation, as well as the underlying metabolic processes involved. The findings could help develop targeted treatments for those affected by this condition.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for patients suffering from uric acid kidney stones.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in various metabolic conditions, suggesting potential success for this approach.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Moe, Orson W — Ut Southwestern Medical Center
- Study coordinator: Moe, Orson W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.