Norepinephrine irrigation to help stop bleeding during flexible ureteroscopic lithotripsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-arm interventional study investigates the safety and effectiveness of a low-concentration norepinephrine irrigation solution used during lithotripsy with a flexible ureteroscope and negative pressure ultrasound sheath. Patients with kidney or upper-urinary tract stones requiring surgery will receive the norepinephrine-containing irrigation to aid hemostasis while the procedure is performed. Outcomes will focus on bleeding control, visualization, stone clearance, and adverse events to determine if this approach is feasible in clinical practice. The trial is conducted at a single center and targets adults up to age 75.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Age 18-75 years of either sex.
* Clinically and radiologically confirmed renal or upper-ureteral stone with operative indication for super flexible ureteroscopic lithotripsy combined with negative pressure ultrasound lithotripsy (su-fURS + NPUAS).
* Subjects with definite surgical indication for upper urinary tract stones, tolerate general anesthesia, and agree to receive the targeted operative procedure.

Exclusion Criteria

* Diagnosis of non-upper urinary tract stones.
* Intolerance to flexible ureteroscopic surgery.
* Poorly-controlled hypertension with blood pressure greater than 160/100 mmHg.
* History of coronary artery disease.

Where it's running

• Geriatric Hospital of Nanjing Medical University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Chuang Wu, Doctor of Medicine
• Email: 813131618@qq.com
• Phone: +8618156836569

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.