Condition
Treatment-Resistant Major Depressive Disorder clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Treatment-Resistant Major Depressive Disorder clinical trials that are recruiting, at sites in 2 countries (most in Canada (2), Spain (1)). By phase: Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 2Countries
Newest Treatment-Resistant Major Depressive Disorder clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Ketamine with DBT for suicidality in adults with treatment-resistant depression or bipolar disorder and BPD | Phase 2 | Toronto, Ontario | Recruiting | May 6, 2026 |
| Virtual reality mindfulness added to usual esketamine care for hard-to-treat depression | — | Barcelona | Recruiting | Feb 20, 2026 |
| Digital health tools for adults with treatment-resistant depression | — | Toronto, Ontario | Recruiting | Dec 13, 2024 |
All recruiting trials (3)
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Ketamine with DBT for suicidality in adults with treatment-resistant depression or bipolar disorder and BPD
This study tests whether four ketamine infusions plus Dialectical Behavioural Therapy can more quickly reduce suicidal thoughts in adults with Borderline Personality Disorder and treatment-resistant depression or bipolar disorder.
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Virtual reality mindfulness added to usual esketamine care for hard-to-treat depression
This will test whether adding a virtual-reality mindfulness program to usual esketamine treatment helps adults with treatment-resistant depression feel less depressed.
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Digital health tools for adults with treatment-resistant depression
This study is testing if digital health tools, like apps and wearable devices, can help adults with treatment-resistant depression track their symptoms and treatment responses while they receive care.
Related topics
Quick answers
How many Treatment-Resistant Major Depressive Disorder clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in Canada (2 trials), Spain (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.