Condition

Major Depressive Episode clinical trials and research

• 17Clinical trials
• 2New in 30 days
• 5Countries

Newest Major Depressive Episode clinical trials

All recruiting trials (17)

• Sensation Seeking and TMS Response in TRD: Does Personality Shape Treatment Outcomes?

  This real-world study tests whether people with treatment-resistant depression who have higher sensation-seeking traits respond differently to TMS treatment.

  Recruiting Technical University of Munich · München, Bavaria · NCT07889739

• Remote monitoring for adults with depression using ThIA Suivi

  This study tests whether adding the ThIA Suivi remote monitoring tool to usual psychiatric care helps adults with depression feel more improved after 3 months compared with standard care alone.

  Recruiting at 3 sites Phase 1 ThIA Santé Mentale · Bron and 2 other locations · NCT07878754

• EEG microstates and inflammatory markers in treatment-resistant depression patients undergoing ECT

  This study tests how electroconvulsive therapy affects brain activity patterns seen in EEG and inflammatory biomarkers in adults with treatment-resistant major depression.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Bakırköy · NCT07748091

• EEG microstates and inflammatory biomarkers in older adults with major depression receiving ECT

  This study tests how ECT affects brain wave patterns and inflammatory markers in people 55 and older with major depression.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Bakırköy · NCT07740694

• Sleep-to-Mood in Depression: Home-based tDCS

  This study tests whether home-based tDCS for adults with moderate depression helps sleep improve and whether better sleep is linked to mood improvements.

  Recruiting NYU Langone Health · New York, New York · NCT07572526

• Light therapy response in unipolar and bipolar major depressive episodes

  This study tests whether light therapy helps adults with a major depressive episode respond to treatment, including those with unipolar or bipolar depression.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07462637

• At‑home tDCS maintenance for depression

  This pilot tests whether an at-home transcranial direct current stimulation (tDCS) program can help adults with depression maintain improvements achieved during inpatient treatment.

  Recruiting Technical University of Munich · München, Bavaria and 1 other locations · NCT07269964

• Digital health tools for adults with treatment-resistant depression

  This study is testing if digital health tools, like apps and wearable devices, can help adults with treatment-resistant depression track their symptoms and treatment responses while they receive care.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT06732089

• Coach-guided personalized depression risk communication to lower the chance of a major depressive episode

  This trial will test whether a coach-guided tool that shows your personalized depression risk and recommends evidence-based self-help steps can lower the chance of a major depressive episode in adults at high risk.

  Recruiting Dalhousie University · Halifax, Nova Scotia · NCT06619366

• New treatment for depression in adolescents using brain stimulation

  This study is testing a new brain stimulation treatment for depression in teens aged 14-19 who haven't tried antidepressants before, to see if it helps them feel better.

  Recruiting University of Texas at Austin · Austin, Texas · NCT06523439

• Comparing Ketamine and Placebo for Severe Depression Treatment

  This study tests if intravenous ketamine can help people with severe depression feel better faster than traditional antidepressants.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Le Kremlin-Bicêtre, France and 3 other locations · NCT06508710

• Imaging brain activity in patients with depression after COVID-19

  This study is trying to see how COVID-19 might affect brain activity in people who have depression after their infection.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06086366

• Measuring blood metabolites during electroconvulsive therapy for depression

  This study is testing if changes in blood substances during electroconvulsive therapy can help predict how well the treatment works for people with major depression or bipolar disorder.

  Recruiting Hôpital le Vinatier · Bron · NCT05973643

• Cohort of patients with major depressive episodes focusing on sleep and biological rhythms

  This study is trying to find out if certain sleep and biological markers can help identify different types of depression in patients to improve how we diagnose and treat it.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Paris · NCT05866991

• Comparing two types of brain stimulation for treatment-resistant depression

  This study is testing if a new type of brain stimulation can help people with treatment-resistant depression just as well as a current method they already use.

  Recruiting at 2 sites University of British Columbia · Vancouver, British Columbia and 1 other locations · NCT04999553

• Registry for patients with treatment-resistant depression and OCD receiving interventional therapies

  This study is testing different treatments like ECT, TMS, and ketamine to see how they help people with treatment-resistant depression and OCD feel better.

  Recruiting University of Iowa · Iowa City, Iowa · NCT04480918

• Using buprenorphine to reduce severe suicidal thoughts in depressed patients

  This study is testing if low doses of buprenorphine can help reduce severe suicidal thoughts in people experiencing major depression.

  Recruiting at 7 sites Phase 3 Centre Hospitalier Universitaire de Nīmes · Bordeaux, France and 8 other locations · NCT03646058

Related topics

Quick answers

How many Major Depressive Episode clinical trials are recruiting right now?

17, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in France (6 trials), Canada (4 trials), United States (3 trials), Turkey (Türkiye) (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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