Condition

Small Cell Lung Cancer Extensive Stage clinical trials and research

• 16Clinical trials
• 1New in 30 days
• 21Countries

Newest Small Cell Lung Cancer Extensive Stage clinical trials

All recruiting trials (16)

• Targeted alpha therapy for B7-H3 expressing solid tumors using AKY-2519

  This phase 1b trial tests a radiolabeled drug (AKY-2519) to see if it's safe and tolerable in adults with B7-H3 positive advanced solid tumors, including NSCLC and SCLC, with imaging to help guide use.

  Recruiting at 2 sites Phase 1 Aktis Oncology, Inc. · Miami, Florida and 1 other locations · NCT07887971

• EASE: A new approach to help adults with advanced cancer cope with fear of progression

  This study tests a written exposure-based coping program to see if it reduces fear of cancer progression and related distress in adults with advanced solid tumors.

  Recruiting at 2 sites University of Colorado, Boulder · Aurora, Colorado and 1 other locations · NCT07636200

• BL-M14D1 plus atezolizumab vs standard therapy in first-line extensive-stage small cell lung cancer

  A first-line treatment for adults with extensive-stage small cell lung cancer tests whether adding BL-M14D1 to atezolizumab and standard chemotherapy helps more than standard care.

  Recruiting at 7 sites Phase 3 SystImmune Inc. · Springdale, Arkansas and 61 other locations · NCT07625644

• DSP-0390 with Atezolizumab in extensive-stage small cell lung cancer

  This pilot phase Ib study tests whether adding DSP-0390 to maintenance atezolizumab after initial chemo-immunotherapy is safe and shows early signs of activity in people with extensive-stage small cell lung cancer who have not progressed.

  Recruiting Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT07545954

• Gocatamig and ifinatamab deruxtecan combined with standard therapy for extensive-stage small cell lung cancer

  This trial tests whether giving gocatamig and ifinatamab deruxtecan, alone or with standard chemotherapy plus immunotherapy, helps people with extensive-stage small cell lung cancer.

  Recruiting at 58 sites Phase 1/2 Merck Sharp & Dohme LLC · Santa Rosa, California and 57 other locations · NCT07227597

• Personalized PULSAR radiotherapy for advanced small cell lung cancer and brain metastases

  This trial will try personalized PULSAR radiotherapy schedules to see if they are safe and helpful for adults with extensive-stage small cell lung cancer who need thoracic radiation and for adults with 1–5 brain metastases.

  Recruiting Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07139990

• MHB088C injection versus physician-chosen chemotherapy for relapsed extensive-stage small cell lung cancer

  This study will test whether MHB088C injection can help adults with relapsed extensive-stage small cell lung cancer live longer than chemotherapy their doctor would normally choose.

  Recruiting Phase 3 Qilu Pharmaceutical Co., Ltd. · Shanghai · NCT06954246

• Combining liposomal irinotecan and apatinib for advanced small cell lung cancer

  This study is testing if combining two drugs, liposomal irinotecan and apatinib, can help people with advanced small cell lung cancer who haven't responded to their first treatment.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06749691

• Combining irinotecan liposome or etoposide with adebrelimab and carboplatin for extensive stage small cell lung cancer

  This study is testing two different treatment combinations to see if they can help people with extensive stage small cell lung cancer live longer and feel better.

  Recruiting Phase 2 Guangzhou Institute of Respiratory Disease · Guangzhou, Guangzhou · NCT06739928

• Adebrelimab plus chemotherapy with concurrent low-dose radiotherapy for extensive-stage small cell lung cancer

  This trial tests whether adding the immunotherapy adebrelimab to standard chemotherapy together with low-dose radiotherapy helps adults with extensive-stage small cell lung cancer live longer or respond better to treatment.

  Recruiting Phase 2 Sichuan University · Sichuan · NCT06610734

• Combining PD-L1 inhibitor with apatinib for treating advanced small cell lung cancer

  This study is testing if a new combination of a PD-L1 inhibitor and apatinib can help people with advanced small cell lung cancer stay cancer-free longer after their initial treatment.

  Recruiting Phase 2 Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT06429696

• Treatment for relapsed small cell lung cancer using CAR-T therapy

  This study is testing a new CAR-T therapy for people with relapsed small cell lung cancer to see if it can help them after other treatments have failed.

  Recruiting Phase 1 Sichuan University · Chengdu, Sichuan · NCT06348797

• Combination therapy for treatment-naïve extensive stage small cell lung cancer

  This study is testing a new combination of treatments for people with extensive-stage small cell lung cancer to see if it works better than the usual options.

  Recruiting Phase 1/2 InxMed (Shanghai) Co., Ltd. · Jinan and 2 other locations · NCT06030258

• Analysis and treatment options for small cell lung cancer

  This study looks at small cell lung cancer to see how its unique features can help doctors find better treatments and predict how well patients will respond to new therapies.

  Recruiting Shanghai Chest Hospital · Shanghai · NCT05945745

• Combination therapy for extensive stage small cell lung cancer

  This study is testing a new combination of treatments for people with extensive stage small cell lung cancer to see if it helps them live longer and feel better than current options.

  Recruiting Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT05745350

• Combination therapy for extensive stage small cell lung cancer

  This study is testing a new combination treatment for patients with extensive stage small cell lung cancer who have responded to their initial therapy to see if it helps them stay healthy longer.

  Recruiting at 16 sites Phase 1/2 Genprex, Inc. · Lone Tree, Colorado and 16 other locations · NCT05703971

Related topics

Quick answers

How many Small Cell Lung Cancer Extensive Stage clinical trials are recruiting right now?

16, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in China (10 trials), United States (7 trials), Germany (2 trials), Greece (2 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 4, Phase 1/2: 3, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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