Condition

CRC (Colorectal Cancer) clinical trials and research

• 23Clinical trials
• 1New in 30 days
• 25Countries

Newest CRC (Colorectal Cancer) clinical trials

All recruiting trials (23)

• Targeted alpha therapy for B7-H3 expressing solid tumors using AKY-2519

  This phase 1b trial tests a radiolabeled drug (AKY-2519) to see if it's safe and tolerable in adults with B7-H3 positive advanced solid tumors, including NSCLC and SCLC, with imaging to help guide use.

  Recruiting at 2 sites Phase 1 Aktis Oncology, Inc. · Miami, Florida and 1 other locations · NCT07887971

• ENPP1/cGAS and FAP in Solid Tumors in Vietnamese Patients

  This Vietnam-based study will test ENPP1, cGAS, and FAP expression in archived tumor samples from Vietnamese adults with solid cancers using immunohistochemistry.

  Recruiting at 2 sites Tam Anh Research Institute · Hanoi, Hanoi and 1 other locations · NCT07808164

• HDM2017 combination therapy in advanced colorectal cancer

  A small and mid-size study tests HDM2017 with standard chemotherapy and targeted drugs to see if it’s safe and may help people with unresectable or metastatic colorectal cancer.

  Recruiting Phase 1/2 Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. · Beijing, Beijing Municipality · NCT07805551

• Retlirafusp alfa with bevacizumab and chemotherapy (with or without short radiotherapy) for colorectal cancer liver metastases

  This study tests whether adding retlirafusp alfa to bevacizumab and chemotherapy, with or without short-course radiotherapy, can help patients with advanced colorectal cancer that has spread to the liver.

  Recruiting Phase 2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07728019

• SHR-1701 with short-course radiotherapy and CAPOX before surgery for locally advanced rectal cancer

  This will test whether adding the drug SHR-1701 to short-course radiotherapy plus CAPOX before surgery helps people with locally advanced rectal cancer.

  Recruiting Phase 2 Tongji Hospital · Wuhan, Hubei · NCT07478731

• TGI-5 alone and with nivolumab for advanced or metastatic solid tumors

  This trial tests whether TGI-5 by itself or combined with nivolumab is safe and can shrink tumors in adults with advanced or metastatic colorectal cancer, melanoma, hepatocellular carcinoma, or non‑small cell lung cancer who have exhausted standard treatments.

  Recruiting Phase 1 Hefei TG ImmunoPharma Co., Ltd. · Shanghai · NCT07376707

• Pressurized intraperitoneal aerosol chemotherapy (PIPAC) with mitomycin or raltitrexed for colorectal cancer spread to the peritoneum

  This Phase I study tests PIPAC with mitomycin or raltitrexed alongside standard systemic chemotherapy to see if it is safe and to find the best dose for people whose colorectal cancer has spread to the peritoneum.

  Recruiting Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Other (Non U.s.) · NCT07349043

• First-line treatment with standard chemotherapy and bevacizumab, with or without INCA33890, for metastatic microsatellite-stable colorectal cancer

  This trial will test whether adding a new drug, INCA33890, to standard chemotherapy and bevacizumab helps people with metastatic microsatellite-stable colorectal cancer respond better or live longer.

  Recruiting at 168 sites Phase 3 Incyte Corporation · Mobile, Alabama and 296 other locations · NCT07284849

• GFH375 combined with cetuximab or chemotherapy for KRAS G12D–mutant solid tumors

  This tests whether adding GFH375 to cetuximab or to standard chemotherapy helps people with advanced solid tumors that have a KRAS G12D mutation.

  Recruiting Phase 1/2 Genfleet Therapeutics (Shanghai) Inc. · Beijing, Beijing Municipality and 3 other locations · NCT07259590

• Multi-channel program using a virtual tribal health educator to boost colorectal cancer screening for American Indian adults in Oklahoma.

  This project will try a virtual tribal community health educator delivered by social media and clinic text messages to see if it increases colorectal cancer screening among American Indian adults aged 45–75 in the IHS Clinton Service Unit.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07254910

• High-throughput tissue processing for clearer 3D images of lung and colorectal cancers

  This project tests a high-throughput tissue-processing and 3D imaging approach to create more detailed tumor images from people with lung or colorectal cancer.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT07239063

• cfDNA blood test using 5mC/5hmC to predict response to EGFR or VEGF targeted therapy in metastatic colorectal cancer

  This project will test if a blood test that measures cfDNA methylation (5mC/5hmC) can tell which people with metastatic colorectal cancer are likely to respond to EGFR- or VEGF-targeted treatments.

  Recruiting City of Hope Medical Center · Duarte, California · NCT07224841

• Blood test measuring cfDNA methylation to predict chemotherapy response in metastatic colorectal cancer

  This project will test whether a blood test that measures cfDNA 5mC/5hmC patterns can predict which people with metastatic colorectal cancer will respond to first-line FOLFOX or FOLFIRI chemotherapy.

  Recruiting City of Hope Medical Center · Duarte, California · NCT07224815

• Non-invasive blood biomarkers to detect colorectal cancer and high-grade adenomas

  This study will test whether new non-invasive blood biomarkers can detect colorectal cancer or high-grade precancerous adenomas in people undergoing colonoscopy or colorectal surgery.

  Recruiting Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis · Castellana Grotte · NCT07153458

• PM8002 (BNT327) with chemotherapy in metastatic colorectal cancer

  This trial tests PM8002 (BNT327) combined with chemotherapy to see if it helps adults with first-line metastatic colorectal cancer that is not MSI-H/dMMR.

  Recruiting at 11 sites Phase 2 BioNTech SE · Beijing, Beijing Municipality and 10 other locations · NCT07133750

• ALX2004 for advanced or metastatic EGFR-expressing solid tumors

  This trial will test ALX2004, an antibody-drug conjugate that targets EGFR, in people with advanced or metastatic non-small cell lung, head and neck, esophageal, or colorectal cancer to see if it is safe and shows tumor activity.

  Recruiting at 11 sites Phase 1 ALX Oncology Inc. · La Jolla, California and 11 other locations · NCT07085091

• Stool-based gene methylation test for early colorectal cancer and adenoma detection

  This project will try a stool-based DNA methylation test to see if it can detect colorectal cancer and adenomas in people aged 40 and older.

  Recruiting Zhejiang Provincial People's Hospital · Hangzhou, Zhejiang · NCT07033156

• NGM120 treatment for cachexia in colorectal cancer

  This trial tests whether the drug NGM120 can help people with colorectal cancer who have cancer cachexia gain or maintain weight and improve symptoms.

  Recruiting at 27 sites Phase 2 NGM Biopharmaceuticals, Inc · Los Angeles, California and 27 other locations · NCT07033026

• Real-time AI system to measure colorectal polyp size during colonoscopy

  This will test a real-time AI tool called EndoAIM that automatically measures polyp diameter during colonoscopies in adults having screening, surveillance, or symptom evaluation.

  Recruiting Chinese University of Hong Kong · Shatin · NCT06957015

• BBO-11818 treatment for adults with KRAS mutant cancer

  This study is testing a new drug called BBO-11818 to see if it can help adults with certain types of cancer that have specific KRAS mutations.

  Recruiting at 17 sites Phase 1 TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) · Los Angeles, California and 16 other locations · NCT06917079

• Investigating ALTA3263 for advanced solid tumors with KRAS mutations

  This study is testing a new oral medication called ALTA3263 to see if it is safe and effective for adults with advanced solid tumors that have KRAS mutations.

  Recruiting at 14 sites Phase 1 Alterome Therapeutics, Inc. · Orlando, Florida and 13 other locations · NCT06835569

• Investigating KQB365 for treating advanced solid tumors

  This study tests if a new treatment called KQB365, alone or with another drug, can help adults with advanced solid tumors that have specific genetic mutations.

  Recruiting at 11 sites Phase 1 Kumquat Biosciences Inc. · Phoenix, Arizona and 10 other locations · NCT06720987

• Evaluating a new treatment for advanced solid tumors

  This study is testing a new treatment called ADU-1805 for people with advanced solid tumors to see how safe it is and how well it works on its own and with another drug.

  Recruiting at 11 sites Phase 1 Sairopa B.V. · Detroit, Michigan and 10 other locations · NCT05856981

Related topics

Quick answers

How many CRC (Colorectal Cancer) clinical trials are recruiting right now?

23, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (11 trials), China (10 trials), Australia (2 trials), Belgium (2 trials), Georgia (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 8, Phase 2: 4, Phase 1/2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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