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B7H3 clinical trials and research
As of November 12, 2026, Find a Trial lists 3 B7H3 clinical trials that are recruiting, at sites in 2 countries (most in United States (2), China (1)). 1 was first registered in the last 30 days. By phase: Phase 1 (2), Early Phase 1 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 1New in 30 days
- 2Countries
Newest B7H3 clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Targeted alpha therapy for B7-H3 expressing solid tumors using AKY-2519 | Phase 1 | Miami, Florida and 1 other locations | Recruiting | Oct 22, 2026 |
| AKY-2519 (B7‑H3 targeted radioligand) for metastatic castration‑resistant prostate cancer | Phase 1 | Irvine, California and 7 other locations | Recruiting | May 12, 2026 |
| Imaging solid tumors using a targeted radioactive probe | Early Phase 1 | Beijing, Beijing Municipality | Recruiting | Jun 12, 2024 |
All recruiting trials (3)
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Targeted alpha therapy for B7-H3 expressing solid tumors using AKY-2519
This phase 1b trial tests a radiolabeled drug (AKY-2519) to see if it's safe and tolerable in adults with B7-H3 positive advanced solid tumors, including NSCLC and SCLC, with imaging to help guide use.
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AKY-2519 (B7‑H3 targeted radioligand) for metastatic castration‑resistant prostate cancer
This trial tests whether AKY‑2519, a B7‑H3–targeted radioactive medicine used for imaging and treatment, is safe and can shrink tumors in men with metastatic castration‑resistant prostate cancer, including those who have had prior 177Lu‑PSMA‑617.
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Imaging solid tumors using a targeted radioactive probe
This study is testing a new radioactive probe to see if it can help improve PET imaging of solid tumors in patients by looking at how well it targets a specific protein found in those tumors.
Related topics
Quick answers
How many B7H3 clinical trials are recruiting right now?
3, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in United States (2 trials), China (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.