Condition

Periapical Periodontitis clinical trials and research

• 8Clinical trials
• 6Countries

Newest Periapical Periodontitis clinical trials

All recruiting trials (8)

• Single-visit Root Canal Outcomes with Different Sealers in Asymptomatic Teeth

  This study tests four root canal filling materials and techniques in single-visit treatments to see how they affect pain after the procedure and healing over a year in people with periapical lesions.

  Recruiting Istanbul Medipol University Hospital · Istanbul, Esenler · NCT07868315

• Accuracy and healing outcomes of endodontic surgery with a 3D-printed static guide

  This trial tests whether using a 3D-printed static surgical guide for apicoectomy improves surgical precision and healing in patients with periapical disease.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City · NCT07734987

• Antibacterial Effect of Bioceramic vs Calcium Hydroxide Medicaments in Root Canals

  This study tests whether Bio-C Temp or UltraCal XS can better reduce bacteria inside root canals of lower molars with chronic apical periodontitis.

  Recruiting Medipol University · Istanbul, Istanbul · NCT07671326

• Hyaluronic acid to improve healing after endodontic microsurgery

  This trial will test whether adding cross-linked hyaluronic acid during endodontic microsurgery helps adults with apical periodontitis of first molars heal faster and have less pain.

  Recruiting University of Bern · Moscow · NCT07501585

• Comparison of root canal disinfection methods for apical periodontitis

  This study tests whether laser-activated irrigation or ultrasonic activation more effectively disinfects teeth with asymptomatic apical periodontitis.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT07439614

• Root canal treatment and cardiovascular risk markers in people with stable coronary artery disease

  This trial tests whether doing a single-visit root canal right away versus delaying it three months changes blood markers of inflammation (hs-CRP and IL-6) in people with stable coronary artery disease who have chronic apical periodontitis.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07343804

• Comparing root canal sealers and filling techniques for healing after treatment

  This will test whether two sealers (AH Plus and NeoSealer Flo) and two obturation techniques (continuous wave and single cone) lead to better x‑ray healing in adults needing root canal treatment.

  Recruiting University of Siena · Madrid, Spain · NCT07019298

• Postoperative pain after root canal filling with bioceramic or resin-based sealers.

  This project will see if using bioceramic versus resin-based sealers for root canal fillings changes short-term pain in adults with pulpitis, pulp necrosis, or previously treated teeth.

  Recruiting University of Siena · Madrid · NCT07018284

Related topics

Quick answers

How many Periapical Periodontitis clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in Turkey (Türkiye) (2 trials), Spain (2 trials), Vietnam (1 trial), United States (1 trial), Russia (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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