Single-visit Root Canal Outcomes with Different Sealers in Asymptomatic Teeth
Official title: Postoperative Pain and Success of Single-Visit Root Canal Treatment Using Different Root Canal Sealers in Asymptomatic Teeth
Run by Istanbul Medipol University Hospital · NCT07868315 · Data updated 2026-11-12
This study tests four root canal filling materials and techniques in single-visit treatments to see how they affect pain after the procedure and healing over a year in people with periapical lesions.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Istanbul Medipol University Hospital Academic / other |
| Locations | 1 site (Istanbul, Esenler) |
| Status | Recruiting |
| Started | April 22, 2025 |
| Main results expected | November 10, 2026 |
| Study ends | November 10, 2027 |
| Registry record updated | October 9, 2026 |
| Trial ID | NCT07868315 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–65 years with a single, asymptomatic tooth having a periapical lesion and suitable for single-visit root canal treatment.
✕Probably not a fit
Patients with symptomatic teeth, complex anatomy, or conditions excluding single-visit treatment may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this interventional study, 200 adults with asymptomatic teeth and periapical lesions will be assigned to four groups using different sealers and techniques: AH Plus with warm gutta-percha, AH Plus with a single-cone method, TotalFill BC Sealer with a single-cone method, and One-Fil with a single-cone method. Postoperative pain will be tracked, and healing will be assessed clinically and with X-ray imaging over 1 month to 1 year using the Periapical Index. The goal is to compare long-term outcomes of these materials and techniques for single-visit root canal treatment.
Why it matters
Potential benefit: If successful, the findings could guide dentists in choosing sealers and techniques that improve pain outcomes and long-term tooth health.
How similar studies have gone: Previous research has explored different sealers and techniques, with mixed results; this study adds direct comparison in a standardized, single-visit setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18-65 years. * Patients classified as ASA Physical Status I or II according to the American Society of Anesthesiologists (ASA) classification: * Teeth that have not previously undergone root canal retreatment or surgical intervention. * Patients who are able to read and sign the informed consent form. * Patients who are physically and mentally able to tolerate the planned dental treatment. * Teeth treated in a single treatment session. Exclusion Criteria: * Pregnant or lactating women. * Patients with chronic periodontal disease and/or a periodontal probing depth \>4 mm. * Symptomatic patients. * Patients who are unable to comply with the scheduled follow-up periods. * Patients who have used analgesics within 1 week or antibiotics within 1 month prior to treatment. * Teeth with root resorption. * Teeth with a vertical root fracture or a risk of vertical root fracture. * Teeth with incomplete root development.
Where it's running
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Istanbul Medipol University, Faculty of Dentistry
Istanbul, Esenler, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: omer albanki, DDS
- Email: omaralbanki1997@gmail.com
- Phone: 00905365927496
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.