Root canal treatment and cardiovascular risk markers in people with stable coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients with stable coronary artery disease and a single necrotic tooth with radiographic apical periodontitis were recruited from dental and cardiology outpatient clinics at PGIDS Rohtak. Baseline clinical, radiographic, and laboratory measures including hs-CRP and IL-6 were recorded. Participants were randomized to immediate single-sitting root canal treatment or to delayed endodontic treatment after three months, with clinical and laboratory reassessments at three months in both groups and an additional post-treatment measurement in the delayed group. The study compares changes in systemic inflammatory biomarkers between the two timing strategies to see if endodontic therapy affects cardiovascular risk markers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Individuals 30 years of age and older, with a diagnosis of stable coronary artery disease (CAD) and chronic apical periodontitis.
2. All patients had to present with CAD defined by the Brazilian Society of Cardiology (Xavier et al., 2013) as the documented occurrence of one or more of the following events 6 months before entering the study: history of myocardial infarction, stable angina or ischaemia in non-invasive tests; surgical or percutaneous myocardial revascularization and lesion size of greater than 50% in at least one major coronary artery, as assessed by angiography; presence of angina and positive results of non-invasive testing of ischaemia.
3. Presence of apical periodontitis defined by the presence of at least 1 radiographic radiolucency ( ≥ 3mm) in teeth as assessed both clinically and radiographically ,with periapical index (PAI) scores ≥3 in a single permanent tooth and pulp necrosis verified by cold and electric pulp test.

   \-

Exclusion Criteria:

1. Chronic conditions associated with periodontitis or with changes in systemic inflammation (e.g. diabetes mellitus, rheumatoid arthritis, rheumatic fever, malignancy, respiratory diseases, renal diseases).
2. Presence of localized or diffuse periodontal disease.
3. Acute symptomatic patients
4. Presence of CV risk factor - history of smoking
5. Acute conditions known to affect systemic inflammatory markers (orthopaedic trauma, surgery ,viral infections)
6. Medications (during last 3 months) known to affect systemic inflammatory markers (systemic steroids,immunosuppressants, hormone replacement therapy, contraceptives and systemic antibiotics
7. Obesity (body mass index \[BMI\]≥30 kg/m2
8. Pregnancy \& Lactation.37

Where it's running

• Post Graduate institute of Dental Sciences, Rohtak
  Rohtak, Haryana, India Recruiting

Study contacts

• Study coordinator: Nishant Chauhan, MDS
• Email: catchnishu619@gmail.com
• Phone: +919991772647

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Single-visit Root Canal Outcomes with Different Sealers in Asymptomatic Teeth

  This study tests four root canal filling materials and techniques in single-visit treatments to see how they affect pain after the procedure and healing over a year in people with periapical lesions.

  Recruiting Istanbul Medipol University Hospital · Istanbul, Esenler · NCT07868315

• Accuracy and healing outcomes of endodontic surgery with a 3D-printed static guide

  This trial tests whether using a 3D-printed static surgical guide for apicoectomy improves surgical precision and healing in patients with periapical disease.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City · NCT07734987

• CARAMEL: Personalizing Heart Risk in Women 40–60

  This observational study tests a personalized cardiovascular risk-stratification approach for women aged 40–60 using multi-source data and a digital self-management tool.

  Recruiting at 3 sites Biogipuzkoa Health Research Institute · Bogotá and 5 other locations · NCT07695376

• Antibacterial Effect of Bioceramic vs Calcium Hydroxide Medicaments in Root Canals

  This study tests whether Bio-C Temp or UltraCal XS can better reduce bacteria inside root canals of lower molars with chronic apical periodontitis.

  Recruiting Medipol University · Istanbul, Istanbul · NCT07671326

• Digital health platform to help prevent and manage high blood pressure, lipids, and kidney and heart disease

  This trial tests a mobile digital health platform to help people with hypertension, dyslipidemia, and related conditions in New Taipei City see if the platform improves blood pressure, cholesterol, and kidney health.

  Recruiting New Taipei City Medical Association · New Taipei City · NCT07588256

• Hyaluronic acid to improve healing after endodontic microsurgery

  This trial will test whether adding cross-linked hyaluronic acid during endodontic microsurgery helps adults with apical periodontitis of first molars heal faster and have less pain.

  Recruiting University of Bern · Moscow · NCT07501585

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.