Antibacterial Effect of Bioceramic vs Calcium Hydroxide Medicaments in Root Canals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial compares two intracanal medicaments, Bio-C Temp (bioceramic) and UltraCal XS (calcium hydroxide), in mandibular molars affected by chronic apical periodontitis. Bacterial load is measured before and after canal preparation, after medicament removal, and after final irrigation using droplet digital PCR. Procedures follow standard endodontic care with rubber dam isolation, chemomechanical preparation, and ultrasonic irrigation; samples are collected at defined points to assess antimicrobial effectiveness. Participants are adults 18–65 years, systemically healthy, requiring primary root canal treatment and presenting periapical radiolucency. The study is conducted at Istanbul Medipol University, under Medipol University as lead sponsor.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged between 18 and 65 years
* Being systemically healthy (ASA I or ASA II)
* Mandibular molar teeth with a radiographically detectable radiolucent lesion in the periapical region
* Willingness of the volunteer or their legal representative to participate in the study by signing the Informed Consent Form

Exclusion Criteria:

* Patients who have received antibiotics or corticosteroids within the last 3 months
* Patients with systemic diseases
* Teeth that cannot be properly isolated with a rubber dam
* Teeth with periodontal pockets \>4 mm and teeth with crown/root fractures
* Individuals who are undergoing or planning to start orthodontic treatment during the study period
* Pregnant or breastfeeding individuals

Where it's running

• Istanbul Medipol University
  Istanbul, Istanbul, Turkey (Türkiye) Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.