Hyaluronic acid to improve healing after endodontic microsurgery
Official title: Effectiveness of Using Cross-linked Hyaluronic Acid in Endodontic Microsurgery. A RCT
Run by University of Bern · NCT07501585 · Data updated 2026-11-12
This trial will test whether adding cross-linked hyaluronic acid during endodontic microsurgery helps adults with apical periodontitis of first molars heal faster and have less pain.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 46 (estimated) |
| Sponsor | University of Bern Academic / other |
| Drugs / interventions | Chemotherapy |
| Locations | 1 site (Moscow) |
| Status | Recruiting |
| Started | February 20, 2026 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2028 |
| Registry record updated | March 30, 2026 |
| Trial ID | NCT07501585 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) with apical periodontitis of a maxillary or mandibular first molar at least 12 months after non-surgical endodontic treatment, good oral hygiene (FMPS and BoP ≤20%), a periapical lesion ≤10 mm, and a four-wall bone defect are ideal candidates.
✕Probably not a fit
Patients who are heavy smokers (>10 cigarettes/day), allergic to hyaluronic acid, pregnant or lactating, have uncontrolled diabetes, untreated periodontal disease, acute infections at the surgical site, or lesions/defects that do not meet the size or morphology criteria are unlikely to benefit or are excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized, double-blinded, parallel-group trial comparing endodontic microsurgery with adjunctive cross-linked hyaluronic acid versus the same surgery without the adjunct in adults with persistent apical periodontitis of first molars. Eligible patients previously treated with non-surgical root canal therapy are allocated to test or control groups and followed for 12 months. Primary outcomes are early soft-tissue healing (Early Wound Healing Score at day 4) and postoperative pain (visual analogue scale), with secondary radiographic healing assessments at 3, 6, and 12 months including CBCT. Blinded outcome examiners evaluate radiographs to determine differences in hard-tissue healing.
Why it matters
Potential benefit: If successful, adjunctive cross-linked hyaluronic acid could speed soft- and hard-tissue healing, reduce postoperative pain, and improve the long-term stability of surgical outcomes.
How similar studies have gone: Hyaluronic acid has shown promising soft-tissue healing benefits in oral and periodontal surgery, but robust randomized evidence specifically in endodontic microsurgery is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Written informed consent * ≥18 years of age * Apical peridontitis at maxillar or mandibular first molars ≥ 12 months after non-surgical endodontical treatment * Full mouth plaque score (FMPS) and bleeding score (BoP) \< or 20% * Periapical lesion \< or 10 mm * Four-wall bone defect morphology Exclusion Criteria: * Smokers of more than 10 cigarettes a day * Allergy to hyaluronic acid * Pregnancy or lactation * Uncontrolled Diabetes * Untreated periodontal conditions * Any conditions associated with poor compliance or failure to maintain good oral hygiene * Acute infections lesions in areas intended for surgery * Chemotherapy and radiotherapy treatment
Where it's running
-
Praktika 1
Moscow, Russia Recruiting
Study contacts
- Study coordinator: Anton Sculean, Prof.
- Email: anton.sculean@unibe.ch
- Phone: +41316840620
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Single-visit Root Canal Outcomes with Different Sealers in Asymptomatic Teeth
This study tests four root canal filling materials and techniques in single-visit treatments to see how they affect pain after the procedure and healing over a year in people with periapical lesions.
-
Accuracy and healing outcomes of endodontic surgery with a 3D-printed static guide
This trial tests whether using a 3D-printed static surgical guide for apicoectomy improves surgical precision and healing in patients with periapical disease.
-
Antibacterial Effect of Bioceramic vs Calcium Hydroxide Medicaments in Root Canals
This study tests whether Bio-C Temp or UltraCal XS can better reduce bacteria inside root canals of lower molars with chronic apical periodontitis.
-
Comparison of root canal disinfection methods for apical periodontitis
This study tests whether laser-activated irrigation or ultrasonic activation more effectively disinfects teeth with asymptomatic apical periodontitis.
-
Root canal treatment and cardiovascular risk markers in people with stable coronary artery disease
This trial tests whether doing a single-visit root canal right away versus delaying it three months changes blood markers of inflammation (hs-CRP and IL-6) in people with stable coronary artery disease who have chronic apical periodontitis.
-
Comparing root canal sealers and filling techniques for healing after treatment
This will test whether two sealers (AH Plus and NeoSealer Flo) and two obturation techniques (continuous wave and single cone) lead to better x‑ray healing in adults needing root canal treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.