Comparison of root canal disinfection methods for apical periodontitis
Official title: Comparison of Different Root Canal Disinfection Protocols for Bacterial Reduction in Teeth With Apical Periodontitis Using Two Analytical Microbiological Methods: a Randomized Clinical Study
Run by State University of New York at Buffalo · NCT07439614 · Data updated 2026-11-12
This study tests whether laser-activated irrigation or ultrasonic activation more effectively disinfects teeth with asymptomatic apical periodontitis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | State University of New York at Buffalo Academic / other |
| Locations | 1 site (Buffalo, New York) |
| Status | Recruiting |
| Started | April 1, 2026 |
| Main results expected | December 2026 |
| Study ends | June 2027 |
| Registry record updated | June 23, 2026 |
| Trial ID | NCT07439614 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults needing endodontic treatment on a molar with intact pulp-chamber walls and asymptomatic apical periodontitis, able to consent and comply with follow-up.
✕Probably not a fit
Patients with immature teeth, extensively destroyed or obliterated canals, prior endodontic treatment, symptomatic disease, significant periodontal pockets, recent antibiotics, diabetes or immune compromise, or pregnancy may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares two supplementary antimicrobial methods used during endodontic treatment for molars with asymptomatic apical periodontitis. Researchers measure bacterial presence before and after instrumentation using both ATP analysis and qPCR, alongside standard disinfection methods. The aim is to determine which approach more effectively reduces bacterial load in the root canal system. Participants are adults requiring molar endodontic treatment and meeting specific dental and health criteria. The study is conducted at the Advance Education in Endodontics Program in Buffalo, NY, led by SUNY Buffalo with no listed collaborators.
Why it matters
Potential benefit: If successful, patients may experience more thorough root canal disinfection, potentially improving treatment outcomes.
How similar studies have gone: Previous work in endodontics has explored advanced disinfection methods, with mixed but generally promising results for laser-activated and ultrasonic activation approaches.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients able to give informed consent and willing/able to comply with study procedures and follow-up. * Molar teeth indicated for endodontic treatment. * Teeth with intact pulp-chamber walls (no extensive coronal destruction). * Necrotic pulp confirmed by pulp testing. * Clinical and radiographic evidence of asymptomatic apical periodontitis. Exclusion Criteria: * Immature teeth * Teeth with calcified or obliterated canals * Teeth with extensive coronal destruction * Teeth with previous endodontic treatment * Symptomatic apical periodontitis * Teeth with periodontal pockets greater than 4 mm * Patients who have received systemic antibiotics in the last 3 months * Patients with a history of diabetes or immune impairment * Pregnant patients
Where it's running
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Advance Education in Endodontics Program
Buffalo, New York, United States Recruiting
Study contacts
- Study coordinator: Stephen Lyon, DDS
- Email: smlyon@buffalo.edu
- Phone: (716) 829-6229
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.