Comparing root canal sealers and filling techniques for healing after treatment
Evaluation of the Success Rate of Endodontic Treatment Using Different Obturation Techniques and Root Canal Sealer Cements: A Randomized Controlled Trial
This will test whether two sealers (AH Plus and NeoSealer Flo) and two obturation techniques (continuous wave and single cone) lead to better x‑ray healing in adults needing root canal treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 270 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Siena Academic / other |
| Locations | 1 site (Madrid, Spain) |
| Trial ID | NCT07019298 on ClinicalTrials.gov |
What this trial studies
The trial enrolls 270 adult patients with irreversible pulpitis or pulpal necrosis and compares radiographic healing using Orstavik's criteria between AH Plus and NeoSealer Flo sealers and between continuous wave and single cone obturation techniques. Clinical and radiographic variables including quality of obturation, lesion healing, and final restoration are recorded. Patients receive a minimum of six months of follow-up with standardized radiographs to determine treatment success. The study will also explore whether a bioceramic sealer (NeoSealer Flo) is effective regardless of the obturation technique used.
Who should consider this trial
Good fit: Adults (18+) with teeth diagnosed with pulpal necrosis or irreversible pulpitis who can provide informed consent are eligible.
Not a fit: Patients with systemic conditions that impair healing, teeth with root fractures, resorption, open apices, or incomplete/poor-quality radiographic records are excluded and unlikely to benefit from the protocol.
Why it matters
Potential benefit: If successful, the results could identify sealer and technique combinations that improve radiographic healing and inform simpler, more reliable choices for root canal treatment.
How similar studies have performed: Previous studies of bioceramic sealers have shown promising radiographic healing in many cases, but results are mixed and outcomes can depend on technique and case selection.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients aged 18 years and older. Teeth with a diagnosis of pulpal necrosis or irreversible pulpitis. Informed consent provided for data usage. Exclusion Criteria: * Patients with systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunosuppression). * Teeth with root fractures, resorption, or open apices. * Incomplete clinical or radiographic records. * Cases with poor-quality radiographs or lack of standardization for evaluation
Where this trial is running
Madrid, Spain
- Universidad Rey Juan Carlos — Madrid, Spain, Spain (Recruiting)
Study contacts
- Study coordinator: Giulia Malvicini, DDS
- Email: giulia.malvicini@student.unisi.it
- Phone: + 39 3487200168
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.