Comparing root canal sealers and filling techniques for healing after treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial enrolls 270 adult patients with irreversible pulpitis or pulpal necrosis and compares radiographic healing using Orstavik's criteria between AH Plus and NeoSealer Flo sealers and between continuous wave and single cone obturation techniques. Clinical and radiographic variables including quality of obturation, lesion healing, and final restoration are recorded. Patients receive a minimum of six months of follow-up with standardized radiographs to determine treatment success. The study will also explore whether a bioceramic sealer (NeoSealer Flo) is effective regardless of the obturation technique used.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients aged 18 years and older. Teeth with a diagnosis of pulpal necrosis or irreversible pulpitis. Informed consent provided for data usage.

Exclusion Criteria:

* Patients with systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunosuppression).
* Teeth with root fractures, resorption, or open apices.
* Incomplete clinical or radiographic records.
* Cases with poor-quality radiographs or lack of standardization for evaluation

Where it's running

• Universidad Rey Juan Carlos
  Madrid, Spain, Spain Recruiting

Study contacts

• Study coordinator: Giulia Malvicini, DDS
• Email: giulia.malvicini@student.unisi.it
• Phone: + 39 3487200168

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Postoperative pain after root canal filling with bioceramic or resin-based sealers.

  This project will see if using bioceramic versus resin-based sealers for root canal fillings changes short-term pain in adults with pulpitis, pulp necrosis, or previously treated teeth.

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• Single-visit Root Canal Outcomes with Different Sealers in Asymptomatic Teeth

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• Antibacterial Effect of Bioceramic vs Calcium Hydroxide Medicaments in Root Canals

  This study tests whether Bio-C Temp or UltraCal XS can better reduce bacteria inside root canals of lower molars with chronic apical periodontitis.

  Recruiting Medipol University · Istanbul, Istanbul · NCT07671326

• Buffered vs conventional local anesthesia for pain and anxiety during dental treatment in children with pulpitis

  This study tests whether buffered local anesthesia reduces pain and anxiety for school-aged children needing dental treatment for pulpitis.

  Recruiting Universidad Autonoma de San Luis Potosí · San Luis Potosí City, San Luis Potosí · NCT07638254

• Hyaluronic acid to improve healing after endodontic microsurgery

  This trial will test whether adding cross-linked hyaluronic acid during endodontic microsurgery helps adults with apical periodontitis of first molars heal faster and have less pain.

  Recruiting University of Bern · Moscow · NCT07501585

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.