Postoperative pain after root canal filling with bioceramic or resin-based sealers.
Official title: Assessment of Postoperative Pain Incidence in Teeth Affected by Pulpitis, Necrosis, or Previously Treated, Following Obturation With Bioceramic or Resin-based Sealers
Run by University of Siena · NCT07018284 · Data updated 2026-11-12
This project will see if using bioceramic versus resin-based sealers for root canal fillings changes short-term pain in adults with pulpitis, pulp necrosis, or previously treated teeth.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 270 (estimated) |
| Sponsor | University of Siena Academic / other |
| Locations | 1 site (Madrid) |
| Status | Recruiting |
| Started | June 1, 2025 |
| Main results expected | December 30, 2025 |
| Study ends | January 30, 2026 |
| Registry record updated | June 12, 2025 |
| Trial ID | NCT07018284 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 and older undergoing root canal treatment for irreversible pulpitis, pulp necrosis, or retreatment who can provide informed consent and have adequate clinical and radiographic records are ideal candidates.
✕Probably not a fit
Patients who are asymptomatic, have root fractures, resorption, open apices, uncontrolled systemic conditions that impair healing, or inadequate radiographs are excluded and unlikely to benefit from this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults (≥18) with teeth diagnosed with irreversible pulpitis, pulp necrosis, or previously treated endodontic cases will receive root canal obturation using either a bioceramic sealer (NeoSealer Flo) or a resin-based sealer (AH Plus) with standardized obturation techniques (single-cone or continuous wave condensation). Patients will record pain intensity on a Visual Analogue Scale immediately after treatment, at 24 hours, and at 72 hours. The primary comparison is the incidence and intensity of early postoperative pain between the two sealer groups to determine whether sealer type influences short-term discomfort. The study is conducted at Universidad Rey Juan Carlos in Madrid in collaboration with the University of Siena.
Why it matters
Potential benefit: If successful, the findings could help clinicians choose obturation materials that reduce short-term pain after root canal treatment.
How similar studies have gone: Prior clinical studies comparing bioceramic and resin-based sealers have shown mixed results, with some suggesting slightly less postoperative pain with bioceramics but no definitive consensus.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients aged 18 years and older. Teeth with a diagnosis of pulpal necrosis or irreversible pulpitis. Informed consent provided for data usage. Exclusion Criteria: * Patients with systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunosuppression). * Asymptomatic presentation * Teeth with root fractures, resorption, or open apices. * Incomplete clinical or radiographic records. * Cases with poor-quality radiographs or lack of standardization for evaluation
Where it's running
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Universidad Rey Juan Carlos , Madrid, Spain 28922
Madrid, Spain Recruiting
Study contacts
- Principal investigator: Simone Grandini, PhD — University of Siena
- Study coordinator: Giulia Malvicini, DDS
- Email: giulia.malvicini@student.unisi.it
- Phone: Italia: +39 3487200168
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Comparing root canal sealers and filling techniques for healing after treatment
This will test whether two sealers (AH Plus and NeoSealer Flo) and two obturation techniques (continuous wave and single cone) lead to better x‑ray healing in adults needing root canal treatment.
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Single-visit Root Canal Outcomes with Different Sealers in Asymptomatic Teeth
This study tests four root canal filling materials and techniques in single-visit treatments to see how they affect pain after the procedure and healing over a year in people with periapical lesions.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.