Understanding how the heart's pacemaker adapts to changes in pressure and volume.
Official title: Functional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac Remodeling
Funded at University of Wisconsin-Madison · NIH-11002675 · Data updated 2026-11-12
This study is looking at how the heart's natural pacemaker reacts to changes in pressure and volume, which could help us understand heart problems like sick sinus syndrome and lead to better treatments for people with irregular heartbeats.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | March 1, 2018 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $552,698 |
| NIH project number | 5R01HL141214-07 |
| Project ID | NIH-11002675 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with hypertension or other conditions that may lead to sick sinus syndrome.
✕Less likely to help
Patients with stable heart conditions that do not involve the sinoatrial node or those without any cardiac issues may not benefit from this research.
What this research studies
This research investigates how the heart's primary pacemaker, the sinoatrial node (SAN), responds to mechanical changes in the heart's environment, such as pressure and volume fluctuations. By using advanced imaging techniques and biochemical studies, the research aims to uncover the mechanisms behind heart rate regulation and how chronic stress can lead to dysfunction in the pacemaker. The goal is to better understand conditions like sick sinus syndrome, which can cause irregular heartbeats and other cardiac issues. This knowledge could pave the way for new preventative strategies and treatments for patients with heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from heart rhythm disorders and enhance overall cardiac health.
How similar studies have gone: Previous research has shown promising results in understanding cardiac function and pacemaker mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Glukhov, Alexey V — University of Wisconsin-Madison
- Study coordinator: Glukhov, Alexey V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.