Investigating a key enzyme that regulates bacterial metabolism
Structure and function of a metabolic pacemaker in bacterial cell membrane
This study is looking at how a special enzyme in bacteria helps them grow and survive, especially when they face infections or antibiotics, and it aims to learn more about how this enzyme works in both making important cell components and managing energy use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10866491 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific enzyme, phosphatidylglycerol phosphatase PgpA, regulates glycolysis in bacteria. By studying the structure and function of PgpA, the researchers aim to uncover its dual role in both phospholipid biosynthesis and as a metabolic regulator. This could provide insights into how bacteria maintain their growth and survival, particularly in the context of infections and antibiotic resistance. The approach involves detailed biochemical assays and mutational analyses to explore the enzyme's regulatory mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from bacterial infections or those at risk of antibiotic-resistant infections.
Not a fit: Patients with viral infections or non-bacterial related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating bacterial infections and antibiotic resistance.
How similar studies have performed: Other research has shown success in targeting metabolic pathways in bacteria, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Zheng, Lei — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Zheng, Lei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.