Using blood tests to monitor head and neck cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on oropharyngeal squamous cell carcinoma (OPSCC), particularly cases associated with human papillomavirus (HPV). The research aims to develop blood-based tests that detect circulating tumor DNA, providing a minimally invasive method for monitoring treatment response and identifying early relapse. By analyzing these DNA fragments shed by tumors, the study seeks to enhance clinical decision-making and improve patient outcomes. The study is set against the backdrop of increasing OPSCC incidence in Scotland and aims to address the limitations of current diagnostic techniques.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with oropharyngeal squamous cell carcinoma
* Both HPV positive and negative disease

Exclusion Criteria:

* Patients under 18 years of age
* Those who lack capacity to consent
* Patients with non-squamous cell carcinoma
* Patients with squamous cell carcinoma out with the oropharynx

Where it's running

• Monklands Hospital ENT
  Airdrie, United Kingdom Recruiting
• Glasgow Royal Infirmary
  Glasgow, United Kingdom Recruiting
• Ninewells Hospital
  Dundee, Dd2 1sg, United Kingdom Not yet recruiting
• Summerfield House - NHS Grampian
  Aberdeen, United Kingdom Not yet recruiting
• The Royal Infirmiry
  Edinburgh, United Kingdom Not yet recruiting

Study contacts

• Principal investigator: Ashley Tay — NHS Lothian
• Study coordinator: Iain Nixon
• Email: Iain.Nixon@nhslothian.scot.nhs.uk
• Phone: 07968498525

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.