Condition

Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 clinical trials and research

• 9Clinical trials
• 2Countries

Newest Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 clinical trials

All recruiting trials (9)

• Adding chemotherapy or chemo-immunotherapy to standard salvage surgery for advanced head and neck cancer

  This trial tests whether giving chemotherapy alone or chemotherapy plus the immunotherapy cemiplimab before salvage surgery helps people with PD-L1–positive recurrent or persistent head and neck squamous cell carcinoma.

  Recruiting at 114 sites Phase 2 National Cancer Institute (NCI) · Tucson, Arizona and 114 other locations · NCT07195734

• Lowering neck radiation dose in HPV-related oropharyngeal cancer

  This trial tests whether giving a lower dose of radiation to the elective neck lymph nodes while treating the primary tumor can maintain good cancer control with fewer side effects in adults with HPV-related oropharyngeal cancer.

  Recruiting at 2 sites Phase 2 Northwestern University · Chicago, Illinois and 1 other locations · NCT07178301

• Comparing two imaging techniques for assessing blood vessel effects in head and neck cancer patients receiving radiation therapy

  This study is testing if a new type of imaging can better spot blood vessel problems in head and neck cancer patients getting radiation therapy compared to the usual imaging method.

  Recruiting Early Phase 1 Emory University · Atlanta, Georgia · NCT06914999

• Adding BMX-001, a drug that protects normal tissue from radiation damage, to standard chemoradiation for head and neck cancer

  This trial tests whether giving BMX-001 along with usual mouth-care reduces severe mouth sores in people getting cisplatin-based chemoradiation for HPV-related and other head and neck cancers.

  Recruiting at 146 sites Phase 2 NRG Oncology · Gilbert, Arizona and 152 other locations · NCT06532279

• Lower dose radiation therapy guided by blood tests for HPV-related throat cancer

  This study is testing if using blood tests to guide lower doses of radiation therapy can help people with HPV-related throat cancer do better than the usual treatment.

  Recruiting Phase 2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT06323460

• Using blood tests to tailor radiation therapy for HPV-positive throat cancer

  This study is testing if blood tests can help doctors decide how much radiation therapy patients with HPV-positive throat cancer really need, aiming to reduce side effects while still effectively treating the cancer.

  Recruiting at 3 sites Phase 2 Mayo Clinic · Scottsdale, Arizona and 2 other locations · NCT05541016

• Combining Ipatasertib with Chemotherapy and Radiation for Head and Neck Cancer

  This study is testing if adding a new drug called ipatasertib to chemotherapy and radiation can help people with advanced head and neck cancer feel better and improve their treatment results.

  Recruiting at 13 sites Phase 1 National Cancer Institute (NCI) · Tampa, Florida and 17 other locations · NCT05172245

• Tailored treatment for HPV-positive oropharyngeal cancer using blood tests

  This study is testing a new way to tailor treatment for people with HPV-related throat cancer by using blood tests to see if adjusting their radiation and chemotherapy can improve their outcomes.

  Recruiting at 2 sites Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT04900623

• Studying how well head and neck cancer patients follow swallowing exercises after radiation

  This study looks at how well people with head and neck cancer stick to their swallowing exercises after radiation treatment and what factors might help or hinder them.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT03010150

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Quick answers

How many Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (9 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Early Phase 1: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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