Condition

Optic Neuritis clinical trials and research

• 10Clinical trials
• 3NIH research projects
• 6Countries

Newest Optic Neuritis clinical trials

All recruiting trials (10)

• Privosegtor for optic neuritis: a late-phase test with standard care

  This trial tests whether privosegtor, added to the usual methylprednisolone treatment, helps people experiencing a first episode of optic neuritis.

  Recruiting at 4 sites Phase 3 Oculis · Livonia, Michigan and 3 other locations · NCT07623668

• Testing the 2022 Optic Neuritis Criteria in suspected cases of optic neuritis

  We’re trying to see if the 2022 criteria can correctly identify optic neuritis in patients with new or recent vision problems, including people with certain antibody types.

  Recruiting at 9 sites First Affiliated Hospital of Guangxi Medical University · Nanning, Guangxi and 8 other locations · NCT07623252

• Early versus rescue plasma exchange for severe optic neuritis and transverse myelitis

  This trial will see if starting plasma exchange early versus using it only as a rescue after high-dose steroids improves vision for adults with severe optic neuritis and improves neurologic recovery for adults with severe transverse myelitis.

  Recruiting at 32 sites Phase 3 Mayo Clinic · Birmingham, Alabama and 34 other locations · NCT07100990

• Efgartigimod to speed vision recovery in acute optic neuritis

  This pilot will test whether efgartigimod given with standard steroids helps adults having their first episode of optic neuritis regain vision faster and more fully than placebo.

  Recruiting at 2 sites Phase 2 Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT06453694

• Using light stimulation to enhance vision after optic neuritis in multiple sclerosis patients

  This study is testing if light stimulation can help improve vision in people with multiple sclerosis who have had optic neuritis.

  Recruiting Technical University of Munich · Munich, Bavaria · NCT06389968

• Using edaravone to treat optic neuritis

  This study is testing if edaravone can help improve vision in Chinese adults who have recently experienced optic neuritis and have a specific antibody in their system.

  Recruiting First Affiliated Hospital of Guangxi Medical University · Nanning · NCT05540262

• Understanding visual pathways in neuro-inflammatory disorders

  This study looks at how optic neuritis affects vision in people with neuroinflammatory diseases like multiple sclerosis to better understand the damage it causes.

  Recruiting University Hospital, Lille · Lille · NCT05487989

• National registry for pediatric inflammatory brain diseases in Switzerland

  This study is collecting information on children with inflammatory brain diseases in Switzerland to see how to better diagnose and treat these conditions.

  Recruiting at 12 sites University of Bern · Aarau, Canton of Aargau and 12 other locations · NCT05017142

• Assessing eye changes in patients with multiple sclerosis

  This study is testing how changes in the eyes of people with multiple sclerosis relate to their condition, using advanced imaging techniques to see if these changes can help us understand the disease better.

  Recruiting Medical University of Vienna · Vienna, Austria · NCT03401879

• Using clemastine to promote healing in optic neuritis

  This study is testing if clemastine, an antihistamine, can help people with optic neuritis heal better by promoting the repair of damaged nerves in their eyes and brain.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT02521311

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Protecting vision in optic neuritis by restoring cholesterol balance

  Researchers are working to restore cholesterol recycling in the eye and brain to protect nerve cells and help preserve vision for people with optic neuritis from MS.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11415641

• Understanding how immune responses damage nerve cells in optic neuritis

  This study is looking at how the immune system can harm nerve cells in the eyes during optic neuritis, which is often seen in multiple sclerosis, and it hopes to find new ways to protect vision by understanding the role of certain proteins in this process.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11066231

• New treatment for optic neuritis using a targeted small molecule inhibitor

  This study is testing a new medication called TRE-515 to help people with optic neuritis, a condition that can cause vision problems, by targeting certain immune cells to reduce inflammation and improve vision.

  NIH research Trethera Corporation · Sherman Oaks, United States · NIH-11031427

Related topics

Quick answers

How many Optic Neuritis clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (4 trials), China (2 trials), Germany (1 trial), France (1 trial), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →