Using edaravone to treat optic neuritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of edaravone on patients with optic neuritis who test positive for aquaporin-4 antibodies. The study aims to determine if edaravone can promote remyelination and protect axons, potentially improving visual outcomes. Eligible participants are Chinese adults experiencing their first episode of optic neuritis within the last 30 days. The trial will assess the efficacy of edaravone as a treatment option for this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Chinese patients aged ≥18 with anti-aquaporin-4 antibody-positive optic neuritis
2. Patients with a first episode of optic neuritis in either eye
3. First symptoms of optic neuritis ≤30 days prior to the first administration of edaravone

Exclusion Criteria:

1. Myopia over 6 diopters
2. Refractive media opacity affecting assessment of retinal layers and/or visual acuity

Where it's running

• Yi Du
  Nanning, China Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Privosegtor for optic neuritis: a late-phase test with standard care

  This trial tests whether privosegtor, added to the usual methylprednisolone treatment, helps people experiencing a first episode of optic neuritis.

  Recruiting at 4 sites Phase 3 Oculis · Livonia, Michigan and 3 other locations · NCT07623668

• Testing the 2022 Optic Neuritis Criteria in suspected cases of optic neuritis

  We’re trying to see if the 2022 criteria can correctly identify optic neuritis in patients with new or recent vision problems, including people with certain antibody types.

  Recruiting at 9 sites First Affiliated Hospital of Guangxi Medical University · Nanning, Guangxi and 8 other locations · NCT07623252

• Early versus rescue plasma exchange for severe optic neuritis and transverse myelitis

  This trial will see if starting plasma exchange early versus using it only as a rescue after high-dose steroids improves vision for adults with severe optic neuritis and improves neurologic recovery for adults with severe transverse myelitis.

  Recruiting at 32 sites Phase 3 Mayo Clinic · Birmingham, Alabama and 34 other locations · NCT07100990

• Efgartigimod to speed vision recovery in acute optic neuritis

  This pilot will test whether efgartigimod given with standard steroids helps adults having their first episode of optic neuritis regain vision faster and more fully than placebo.

  Recruiting at 2 sites Phase 2 Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT06453694

• Using light stimulation to enhance vision after optic neuritis in multiple sclerosis patients

  This study is testing if light stimulation can help improve vision in people with multiple sclerosis who have had optic neuritis.

  Recruiting Technical University of Munich · Munich, Bavaria · NCT06389968

• Understanding visual pathways in neuro-inflammatory disorders

  This study looks at how optic neuritis affects vision in people with neuroinflammatory diseases like multiple sclerosis to better understand the damage it causes.

  Recruiting University Hospital, Lille · Lille · NCT05487989

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.