National registry for pediatric inflammatory brain diseases in Switzerland

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Swiss Pediatric Inflammatory Brain Disease Registry collects comprehensive data on pediatric patients diagnosed with inflammatory brain diseases, including conditions like optic neuritis and multiple sclerosis. Implemented in 2020, it aims to improve diagnosis, treatment, and management of these conditions through systematic data collection across multiple centers in Switzerland. The registry facilitates research and enhances collaboration among clinicians and researchers, ultimately striving to optimize healthcare and quality of life for affected children.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All patients living and/or treated in Switzerland with an IBrainD specified in the following list diagnosed from 2005 onward and with a disease onset before the age of 18.

* Written informed consent by patients (and/or legal representative(s), if applicable)
* Optic Neuritis
* Transverse Myelitis
* Acute disseminated encephalomyelitis
* Multiple Sclerosis
* Neuromyelitis Optica Spectrum Disorders
* Myelin oligodendrocyte glycoprotein antibody-associated disease
* Anti-NMDA-R Encephalitis
* Anti-GAD65 Associated Autoimmune Encephalitis
* Anti-AMPAR-1/2 Associated Autoimmune Encephalitis
* Anti-Lgi-1 Associated Autoimmune Encephalitis
* Anti-CASPR-2 Associated Autoimmune Encephalitis
* Anti-GABAR-1/2 Associated Autoimmune Encephalitis
* Onconeuronal Antibody (Hu, Ri, Yo, Amphiphysin, CRMP-5, Ma-1, Ma-2, SOX-1) Associated Autoimmune Encephalitis
* Hashimoto Encephalopathy
* CNS Vasculitis
* CNS Sarcoidosis
* CNS Lupus
* Rasmussen Encephalitis

Exclusion Criteria:

* Neurological symptoms due to infectious diseases of the CNS
* Genetic/metabolic causes of central demyelinating diseases
* Neurological symptoms due to Guillain-Barré-Syndrome

Where it's running

• Kantonsspital Aarau
  Aarau, Canton of Aargau, Switzerland Recruiting
• Children's Hospital of Eastern Switzerland
  Sankt Gallen, Canton of St. Gallen, Switzerland Recruiting
• University Children's Hospital Lausanne (CHUV)
  Lausanne, Canton of Vaud, Switzerland Recruiting
• Kantonsspital Winterthur
  Winterthur, Canton of Zurich, Switzerland Recruiting
• Pediatric Institute of Southern Switzerland, Ospedale San Giovanni
  Bellinzona, Canton Ticino, Switzerland Recruiting
• Kantonsspital Graubünden
  Chur, Kanton Graubünden, Switzerland Recruiting

Study contacts

• Principal investigator: Sandra Bigi, PD MD — ISPM, University of Bern, Bern; Kinderspital Zentralschweiz, Luzern
• Study coordinator: Lorena F Hulliger, MSc
• Email: lorena.hulliger@unibe.ch
• Phone: +41316845678

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Identifying biomarkers for autoimmune diseases affecting the nervous system

  This study is trying to find specific markers in the blood of people with autoimmune diseases affecting the nervous system, like Multiple Sclerosis, to help with early diagnosis and better treatment options.

  Recruiting Tongji Hospital · Wuhan · NCT06502015

• Using Calculus Bovis Sativus to treat inflammatory demyelinating diseases

  This study is testing if a traditional Chinese medicine called Calculus Bovis Sativus can help people with conditions like multiple sclerosis feel better and reduce inflammation.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT06474520

• Using CT103A cells to treat autoimmune diseases of the nervous system

  This study is testing if a new treatment using CT103A cells can help people with certain autoimmune diseases affecting the nervous system feel better.

  Recruiting Early Phase 1 Tongji Hospital · Wuhan, Hubei · NCT04561557

• OPM-MEG Brain Imaging in Young People with Immune- and Non-immune Related Neurological Disease

  Researchers will test a fancy, child-friendly brain scan (OPM-MEG) to see how brain networks look in kids with autoimmune or other brain diseases and how that relates to their symptoms.

  Recruiting at 2 sites Aston University · Birmingham, West Midlands and 1 other locations · NCT07689682

• Pregnant Women with Neuroimmune Diseases: A long-term follow-up study

  This study follows women with neuroimmune diseases and healthy controls through pregnancy and up to ten years to see how pregnancy affects disease activity and outcomes for both mother and baby.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT07653984

• Using ultra-high field and metabolic MRI to understand resilience and degeneration in the aging and diseased brain

  This project will try advanced 3T and 7T MRI scans, including sodium and phosphorus imaging, to see if metabolic and connectivity changes explain resilience and degeneration in adults with MS, NMOSD, MOGAD, Alzheimer’s, Parkinson’s, or healthy aging.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT07202494

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.