Understanding how immune responses damage nerve cells in optic neuritis
Mechanisms of immune-mediated neuronal damage in a mouse model of optic neuritis
This study is looking at how the immune system can harm nerve cells in the eyes during optic neuritis, which is often seen in multiple sclerosis, and it hopes to find new ways to protect vision by understanding the role of certain proteins in this process.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11066231 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which immune-mediated damage occurs in nerve cells during optic neuritis, a common symptom of multiple sclerosis. Using a mouse model, the study focuses on how immune cells can destabilize microtubules in neurons, leading to inflammation and potential vision loss. The researchers aim to uncover the underlying processes that contribute to neuronal damage, which could help in developing new therapeutic strategies. By examining the role of tau protein and its hyperphosphorylation, the study seeks to provide insights that could be applicable to other neurodegenerative conditions as well.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis who experience symptoms of optic neuritis.
Not a fit: Patients with optic neuritis not related to multiple sclerosis or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for optic neuritis and potentially other neurodegenerative diseases by targeting the mechanisms of neuronal damage.
How similar studies have performed: Previous research has shown promising results in understanding immune-mediated neuronal damage in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Sommers, Kelli C — Medical College of Wisconsin
- Study coordinator: Sommers, Kelli C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.