Understanding visual pathways in neuro-inflammatory disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the mechanisms underlying neurodegeneration in patients with optic neuritis, a condition often associated with neuroinflammatory diseases like multiple sclerosis. By utilizing clinical examinations and advanced imaging techniques such as MRI and optical coherence tomography, the study seeks to explore the relationship between inflammatory lesions and clinical disability. The goal is to establish a clearer understanding of the pathophysiology of these disorders and identify potential causes of neurodegeneration. Participants will be closely monitored to gather data on their condition and response to the study parameters.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \- Male or female
* Aged between 18 and 65 years
* Presenting a clinical picture of optic neuritis for less than 4 weeks, confirmed by neuro-ophthalmological assessment
* Patient having given written consent to participate in the study
* Patient with social insurance
* Patient willing to comply with all study procedures and duration

Exclusion Criteria:

* \- history of optic neuritis on the same side as the recent episode for which the patient is being treated
* history of retinal pathology (retinal detachment, glaucoma, retinopathies, retinal surgery)
* diabetes
* chronic alcohol intoxication
* contraindications to MRI
* pregnant women
* persons under protective supervision (ex : guardianship)
* minors
* persons deprived of their liberty
* administrative reasons: inability to receive informed information, inability to participate in the entire study, lack of social security coverage, refusal to sign consent

A history of pre-existing CNS inflammatory demyelinating disease is not a criterion for non-inclusion.

Where it's running

• Hop Fontan Chu
  Lille, France Recruiting

Study contacts

• Principal investigator: Olivier OUTTERYCK, MD — University Hospital, Lille
• Study coordinator: Olivier OUTTERYCK, MD
• Email: olivier.outteryck@chu-lille.fr
• Phone: 0320445962

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Privosegtor for optic neuritis: a late-phase test with standard care

  This trial tests whether privosegtor, added to the usual methylprednisolone treatment, helps people experiencing a first episode of optic neuritis.

  Recruiting at 4 sites Phase 3 Oculis · Livonia, Michigan and 3 other locations · NCT07623668

• Testing the 2022 Optic Neuritis Criteria in suspected cases of optic neuritis

  We’re trying to see if the 2022 criteria can correctly identify optic neuritis in patients with new or recent vision problems, including people with certain antibody types.

  Recruiting at 9 sites First Affiliated Hospital of Guangxi Medical University · Nanning, Guangxi and 8 other locations · NCT07623252

• Early versus rescue plasma exchange for severe optic neuritis and transverse myelitis

  This trial will see if starting plasma exchange early versus using it only as a rescue after high-dose steroids improves vision for adults with severe optic neuritis and improves neurologic recovery for adults with severe transverse myelitis.

  Recruiting at 32 sites Phase 3 Mayo Clinic · Birmingham, Alabama and 34 other locations · NCT07100990

• Efgartigimod to speed vision recovery in acute optic neuritis

  This pilot will test whether efgartigimod given with standard steroids helps adults having their first episode of optic neuritis regain vision faster and more fully than placebo.

  Recruiting at 2 sites Phase 2 Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT06453694

• Using light stimulation to enhance vision after optic neuritis in multiple sclerosis patients

  This study is testing if light stimulation can help improve vision in people with multiple sclerosis who have had optic neuritis.

  Recruiting Technical University of Munich · Munich, Bavaria · NCT06389968

• Using edaravone to treat optic neuritis

  This study is testing if edaravone can help improve vision in Chinese adults who have recently experienced optic neuritis and have a specific antibody in their system.

  Recruiting First Affiliated Hospital of Guangxi Medical University · Nanning · NCT05540262

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.