Understanding visual pathways in neuro-inflammatory disorders
Study of the VIsual Pathways MODEL for a Better Understanding of Neurodegeneration in Inflammatory and Demyelinating Disorders of Central Nervous System
This study looks at how optic neuritis affects vision in people with neuroinflammatory diseases like multiple sclerosis to better understand the damage it causes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University Hospital, Lille Academic / other |
| Locations | 1 site (Lille) |
| Trial ID | NCT05487989 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the mechanisms underlying neurodegeneration in patients with optic neuritis, a condition often associated with neuroinflammatory diseases like multiple sclerosis. By utilizing clinical examinations and advanced imaging techniques such as MRI and optical coherence tomography, the study seeks to explore the relationship between inflammatory lesions and clinical disability. The goal is to establish a clearer understanding of the pathophysiology of these disorders and identify potential causes of neurodegeneration. Participants will be closely monitored to gather data on their condition and response to the study parameters.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 who have experienced optic neuritis for less than four weeks and have been confirmed through neuro-ophthalmological assessment.
Not a fit: Patients with a history of optic neuritis on the same side as the recent episode or those with significant retinal pathology may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of optic neuritis and related neuro-inflammatory conditions.
How similar studies have performed: While the specific approach of this study may be novel, similar studies have shown promise in understanding neuroinflammatory disorders through advanced imaging techniques.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \- Male or female * Aged between 18 and 65 years * Presenting a clinical picture of optic neuritis for less than 4 weeks, confirmed by neuro-ophthalmological assessment * Patient having given written consent to participate in the study * Patient with social insurance * Patient willing to comply with all study procedures and duration Exclusion Criteria: * \- history of optic neuritis on the same side as the recent episode for which the patient is being treated * history of retinal pathology (retinal detachment, glaucoma, retinopathies, retinal surgery) * diabetes * chronic alcohol intoxication * contraindications to MRI * pregnant women * persons under protective supervision (ex : guardianship) * minors * persons deprived of their liberty * administrative reasons: inability to receive informed information, inability to participate in the entire study, lack of social security coverage, refusal to sign consent A history of pre-existing CNS inflammatory demyelinating disease is not a criterion for non-inclusion.
Where this trial is running
Lille
- Hop Fontan Chu — Lille, France (Recruiting)
Study contacts
- Principal investigator: Olivier OUTTERYCK, MD — University Hospital, Lille
- Study coordinator: Olivier OUTTERYCK, MD
- Email: olivier.outteryck@chu-lille.fr
- Phone: 0320445962
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.