Condition

Oligometastasis clinical trials and research

• 14Clinical trials
• 3NIH research projects
• 11Countries

Newest Oligometastasis clinical trials

All recruiting trials (14)

• Adding targeted stereotactic body radiation therapy to standard systemic treatment for people with oligometastatic urothelial (bladder) carcinoma.

  This study will test whether adding stereotactic body radiation therapy (SBRT) to usual systemic treatment helps people with urothelial (bladder) cancer who have up to three extracranial metastases.

  Recruiting Istituto Clinico Humanitas · Rozzano, Milan · NCT07413523

• Stereotactic body radiotherapy for extracranial oligometastatic breast cancer

  This project sees if stereotactic body radiotherapy (SBRT) helps control cancer and extend survival in adults with extracranial oligometastatic breast cancer.

  Recruiting at 9 sites Istituto Clinico Humanitas · Benevento, Benevento and 27 other locations · NCT07397585

• Stereotactic body radiotherapy (SABR) for limited metastases

  This program tries stereotactic body radiotherapy (SABR) in people with up to five oligometastatic or oligoprogressive cancer lesions to see if it controls disease better, affects symptoms and side effects, and changes ctDNA in the blood.

  Recruiting Samsung Medical Center · Seoul · NCT07121335

• Immediate simulation-free SBRT for people with up to five metastatic tumors

  This tests whether giving stereotactic body radiation therapy (SBRT) right away without a separate CT simulation helps people with up to five metastatic cancer spots get treatment faster.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07079098

• Ablation therapy for lung metastases in advanced liver cancer

  This study tests whether a new treatment combining image-guided ablation therapy with standard care can help people with advanced liver cancer that has spread to the lungs feel better and live longer.

  Recruiting Sun Yat-sen University · Beijing, Beijing Municipality · NCT06644430

• Stereotactic Ablative Radiotherapy for metastatic cancer treatment

  This study tests if starting stereotactic ablative radiotherapy right away helps people with newly diagnosed metastatic lung, colorectal, or prostate cancer live longer compared to waiting three months to start treatment.

  Recruiting Phase 3 Roswell Park Cancer Institute · Buffalo, New York · NCT06563388

• Ablation combined with lenvatinib and PD-1 inhibitor for advanced liver cancer with limited metastases

  This study is testing if combining a targeted treatment with a special type of therapy can help people with advanced liver cancer that has spread a little, to see if it improves their chances of living longer.

  Recruiting Sun Yat-sen University · Beijing, None Selected · NCT06550921

• Treatment for Oligometastatic Breast Cancer

  This study is testing if adding a special treatment for metastatic breast cancer, like surgery or targeted radiation, can help patients do better after starting their regular cancer therapy.

  Recruiting Phase 3 Tokyo Medical and Dental University · Bunkyō-Ku, Tokyo · NCT06135714

• Treatment for recurrent prostate cancer with metastases

  This study is testing whether combining hormone therapy with targeted radiation or surgery can help men with recurrent prostate cancer live longer without their cancer spreading.

  Recruiting Phase 3 Universitaire Ziekenhuizen KU Leuven · Leuven · NCT05352178

• Using stereotactic body radiotherapy for patients with rare oligometastatic cancers

  This study is testing if adding a special type of targeted radiation therapy to standard treatment can help people with rare cancers that have spread to a few places live longer and feel better.

  Recruiting at 13 sites European Organisation for Research and Treatment of Cancer - EORTC · Anderlecht and 12 other locations · NCT04498767

• Testing a new type of radiotherapy using an MR-Linac device

  This study tests a new type of radiotherapy using a special machine that combines imaging and treatment to see if it can better target tumors while protecting healthy tissue.

  Recruiting University Hospital Tuebingen · Tübingen, Baden-Wurttemberg · NCT04172753

• Comparing radical and palliative treatments for breast cancer with specific bone metastases

  This study is testing whether aggressive treatment for breast cancer with specific bone metastases can help patients feel better and live longer compared to just focusing on pain relief.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 3 other locations · NCT04158843

• Registry to assess adverse events from ablative radiotherapy in metastatic cancer

  This study is trying to collect information about side effects from a specific type of radiation treatment for adults with metastatic cancer to better understand how safe it is.

  Recruiting at 5 sites Duke University · Cary, North Carolina and 4 other locations · NCT04085029

• Chemotherapy with or without radiation or surgery for oligometastatic esophageal or gastric cancer

  This study is testing if adding radiation or surgery to chemotherapy helps people with oligometastatic esophageal or gastric cancer live longer and feel better.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT03161522

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• ROBIN OligoMET Center: Radiation and Biology Insights for Prostate Cancer Metastasis

  A nationwide collaboration is testing how targeted radiation can alter the spread of prostate cancer that has few metastases, with the goal of improving control of the disease.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11358355

• Understanding Radiation for Prostate Cancer with Limited Spread

  This research brings together experts to learn how radiation therapy can help patients with prostate cancer that has spread to only a few spots.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11171427

• Investigating how radiation therapy can improve treatment for limited metastatic prostate cancer.

  This study is looking at how radiation therapy can help men with prostate cancer that has spread to a few places in the body, aiming to see if it can stop the cancer from getting worse and improve treatment options for patients.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-10910075

Related topics

Quick answers

How many Oligometastasis clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (4 trials), Italy (3 trials), China (3 trials), Germany (2 trials), Belgium (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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