Condition

Oligometastatic Disease clinical trials and research

• 22Clinical trials
• 17Countries

Newest Oligometastatic Disease clinical trials

All recruiting trials (22)

• Immediate simulation-free SBRT for people with up to five metastatic tumors

  This tests whether giving stereotactic body radiation therapy (SBRT) right away without a separate CT simulation helps people with up to five metastatic cancer spots get treatment faster.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07079098

• Stereotactic ablative radiotherapy versus single‑fraction palliative radiotherapy for oligoprogressive metastatic cancer

  This trial will test whether stereotactic ablative radiotherapy (SABR) works better than single‑fraction palliative radiotherapy (8 Gy) for people with 1–5 oligoprogressive metastatic lesions to delay the need for next‑line systemic therapy and improve quality of life.

  Recruiting British Columbia Cancer Agency · Surrey, British Columbia · NCT06918951

• Chemoimmunotherapy followed by surgery for limited spread esophageal and gastric cancer

  This study is testing if a combination of chemotherapy, immunotherapy, and surgery can help people with a limited spread of esophageal or gastric cancer live longer and have fewer recurrences.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06668454

• Combining radiotherapy with systemic therapy for oligometastatic ureter cancer

  This study tests if adding radiotherapy to standard treatment can help people with a limited number of metastatic ureter cancer spots feel better and live longer.

  Recruiting at 2 sites Peking University First Hospital · Beijing and 1 other locations · NCT06652022

• Stereotactic radiotherapy for patients with oligometastatic cancer

  This study tests whether a special type of targeted radiation therapy can help people with a few metastatic tumors feel better compared to standard care after chemotherapy.

  Recruiting Phase 2/3 National Medical Research Radiological Centre of the Ministry of Health of Russia · Obninsk, Kaluga Oblast · NCT06556550

• Single‑fraction versus multiple‑fraction SBRT for treating limited metastases (SPRINT)

  This trial will test whether a single high‑dose SBRT treatment works as safely and effectively as multiple smaller SBRT treatments for people with limited metastases from breast, prostate, lung, or colorectal cancer.

  Recruiting at 2 sites European Organisation for Research and Treatment of Cancer - EORTC · Aalst and 14 other locations · NCT06462963

• Combining radiation therapy with ATRA for treating oligo-metastatic solid cancers

  This study is testing whether combining a specific type of radiation therapy with a medication called ATRA can help people with certain solid cancers that have spread to a few places in the body.

  Recruiting Phase 1/2 Gustave Roussy, Cancer Campus, Grand Paris · Lyon and 1 other locations · NCT06439888

• Real-time imaging of atherosclerosis activity after radiation therapy for cancer

  This study is testing whether special imaging can help doctors see how radiation therapy for cancer affects heart health in patients at risk for heart problems.

  Recruiting Early Phase 1 Cedars-Sinai Medical Center · Los Angeles, California · NCT06373497

• Long-term assessment of local therapy for oligometastatic disease

  This study is testing different local treatments for people with oligometastatic cancer to see how well they work over time and to help choose the best options for patients.

  Recruiting Herlev Hospital · Copenhagen, Capital Region of Denmark and 10 other locations · NCT06356779

• Treatment for patients with oligometastatic esophageal cancer using PD-1 inhibitors and local therapy

  This study is testing if adding local treatments like surgery or radiation to a PD-1 inhibitor and chemotherapy can help people with oligometastatic esophageal cancer live longer without their cancer getting worse.

  Recruiting Phase 3 Fudan University · Shanghai · NCT06190782

• Niraparib treatment after surgery for ovarian cancer patients with limited metastasis

  This study is testing if a medication called niraparib can help women with certain types of ovarian cancer live longer without their cancer getting worse after surgery.

  Recruiting at 14 sites Phase 2 MedSIR · A Coruña and 13 other locations · NCT06180356

• Combining radiotherapy and immunotherapy for limited metastatic gastric cancer

  This study is testing a new treatment that combines radiation, chemotherapy, and immunotherapy to see if it can help people with limited metastatic gastric cancer live longer and improve their health.

  Recruiting Phase 2 Fudan University · Shanghai · NCT06121700

• Combining radiation therapy with immunotherapy and targeted therapy for liver cancer

  This study is testing whether combining a type of radiation therapy with two cancer drugs can help people with hard-to-treat liver cancer live longer without their disease getting worse.

  Recruiting Phase 2 Peking University Cancer Hospital & Institute · Beijing, Beijing Municipality · NCT05917431

• Observational study of SBRT for patients with rare tumors and oligometastases

  This study is testing how well a special type of radiation therapy works for patients with rare tumors that have spread to a few other places in the body.

  Recruiting Istituto Clinico Humanitas · Rozzano, Milan · NCT05903261

• Comparing single and multiple doses of radiation therapy for treating oligometastatic disease

  This study is testing whether one dose or several doses of radiation therapy works better and is safer for people with oligometastatic disease, while also looking at how it affects their quality of life and costs.

  Recruiting at 13 sites British Columbia Cancer Agency · Kelowna, British Columbia and 13 other locations · NCT05784428

• Comparing two radiation therapies for treating bone metastases in cancer patients

  This study is testing two different types of radiation therapy for cancer patients with bone metastases to see which one works better in treating their condition.

  Recruiting IRCCS San Raffaele · Milan, MI · NCT05679427

• Stereotactic Ablative Radiotherapy for Oligometastatic Breast Cancer

  This study is testing if adding a special type of targeted radiation therapy to standard treatment can help people with oligometastatic breast cancer live longer and feel better.

  Recruiting at 19 sites Phase 3 Vastra Gotaland Region · Cork and 18 other locations · NCT05377047

• Treatment for recurrent prostate cancer with metastases

  This study is testing whether combining hormone therapy with targeted radiation or surgery can help men with recurrent prostate cancer live longer without their cancer spreading.

  Recruiting Phase 3 Universitaire Ziekenhuizen KU Leuven · Leuven · NCT05352178

• Comparing maintenance therapy with radiation for lung cancer patients with limited metastases

  This study is testing if adding radiation therapy to standard treatment can help lung cancer patients with a few spots of cancer live better and longer.

  Recruiting Phase 3 Tata Memorial Hospital · Mumbai, Maharashtra · NCT05278052

• Combining targeted therapy with radiation for specific lung cancer patients

  This study is testing if adding radiation therapy to a targeted cancer treatment can help people with a specific type of lung cancer feel better compared to just using the targeted treatment alone.

  Recruiting Phase 2 Tata Memorial Hospital · Mumbai, Maharashtra · NCT05277844

• Improving treatment for prostate cancer with metastases at diagnosis

  This study is testing if adding a special type of radiation therapy to standard treatment helps men with newly diagnosed prostate cancer that has spread feel better and live longer.

  Recruiting at 10 sites Phase 2 University of Maryland, Baltimore · La Jolla, California and 9 other locations · NCT05223803

• MR‑guided short-course high-dose radiation for prostate cancer (SMART‑P01 & P02)

  This trial tests MR‑guided, very short-course high‑dose radiation for men with localized or limited metastatic prostate cancer to see if it is tolerable and effective.

  Recruiting Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT05183074

Related topics

Quick answers

How many Oligometastatic Disease clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in China (5 trials), Italy (4 trials), Canada (3 trials), United States (3 trials), India (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 3: 4, Phase 2/3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →