Condition

NSCLC Stage IV clinical trials and research

• 20Clinical trials
• 12Countries

Newest NSCLC Stage IV clinical trials

All recruiting trials (20)

• Sacituzumab tirumotecan plus furmonertinib for advanced EGFR‑mutant non‑squamous lung cancer after EGFR‑TKI and platinum chemotherapy

  This Phase II trial will test whether combining sacituzumab tirumotecan with furmonertinib helps people with advanced EGFR‑mutant non‑squamous NSCLC who progressed after EGFR‑TKI and platinum chemotherapy.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT07548060

• Real-world first-line atezolizumab for stage IV NSCLC with PD-L1 ≥50% in Türkiye

  This project will see how well first-line atezolizumab works and how safe it is for adults with stage IV non-small cell lung cancer whose tumors have PD-L1 ≥50% and no targetable mutations in routine care in Türkiye.

  Recruiting at 15 sites Antalya Training and Research Hospital · Adana and 24 other locations · NCT07279402

• Predicting responses in metastatic lung cancer using AI

  This study is testing an AI tool to see if it can help doctors predict how well patients with advanced lung cancer will respond to immunotherapy and chemo-immunotherapy treatments.

  Recruiting IRCCS San Raffaele · Milan · NCT06788366

• Combination treatment for advanced lung cancer

  This study is testing a new combination treatment for advanced lung cancer to see if it works better than the standard single drug treatment.

  Recruiting at 47 sites Phase 3 ImmunityBio, Inc. · Hot Springs, Arkansas and 48 other locations · NCT06745908

• Testing Repotrectinib in Elderly and Frail Patients with Advanced NSCLC

  This study is testing a new cancer drug called repotrectinib to see if it helps older and frail patients with advanced lung cancer feel better and tolerate the treatment well.

  Recruiting at 20 sites Phase 2 Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer · Aix-en-Provence, Bouches Du Rhône and 19 other locations · NCT06552234

• Using Stereotactic Body Radiotherapy for treating metastatic lung cancer with limited progression

  This study is testing if adding a special type of radiation therapy to standard treatment can help people with advanced lung cancer live longer and feel better after their first round of chemotherapy.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06523673

• Combining hormone therapy and immunotherapy for advanced lung cancer

  This study is testing if combining hormone therapy with a type of immunotherapy can help older men with advanced lung cancer respond better to treatment.

  Recruiting Jinzhou Medical University · Zhengzhou, Henan · NCT06512207

• Combining cranial radiotherapy with chemoimmunotherapy for lung cancer patients with brain metastasis

  This study is testing if combining brain radiation with a new type of immunotherapy and chemotherapy can help people with advanced lung cancer and brain metastases live longer and better.

  Recruiting Phase 2 Fudan University · Shanghai · NCT06501391

• Outpatient pulmonary rehabilitation for lung cancer patients on immunotherapy

  This study is testing whether adding a 6-week outpatient rehab program to standard treatment can help improve the quality of life and exercise ability of lung cancer patients on immunotherapy.

  Recruiting Karl Landsteiner Institute for Lung Research and Pneumological Oncology · Vienna · NCT06436625

• Combining sacituzumab govitecan and bevacizumab for treating brain metastases in lung cancer

  This study is testing if a combination of two drugs, sacituzumab govitecan and bevacizumab, can help shrink brain tumors in patients with lung cancer who haven't responded to other treatments.

  Recruiting at 3 sites Phase 2 Maastricht University Medical Center · Amsterdam and 2 other locations · NCT06401824

• Peptide vaccine to prevent resistance in advanced lung cancer

  This study is testing a new vaccine to see if it can help people with advanced lung cancer who are on specific treatments avoid or delay their cancer from becoming resistant.

  Recruiting Phase 1/2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT05950139

• Analysis of rare mutations in non-small cell lung cancer patients

  This study looks at rare genetic changes in people with non-small cell lung cancer to see if understanding these changes can lead to better treatment options.

  Recruiting at 2 sites Shanghai Chest Hospital · Shanghai, Shanghai Municipality and 1 other locations · NCT05701787

• Targeted radiation therapy for advanced lung cancer

  This study is testing if adding a special type of radiation therapy to regular drug treatment can help people with advanced lung cancer that has spread to the liver feel better and live longer.

  Recruiting at 9 sites Phase 2 Memorial Sloan Kettering Cancer Center · Miami, Florida and 8 other locations · NCT05657873

• M701 treatment for malignant pleural effusions from advanced non-small cell lung cancer

  This trial tries M701 injected into the pleural space to see if it reduces fluid build-up and helps adults with stage IV NSCLC who have needed first-line treatment.

  Recruiting Phase 1/2 Wuhan YZY Biopharma Co., Ltd. · Hangzhou, Zhejiang · NCT05543330

• Combining anti-PD-1/PD-L1 treatment with UV1 vaccination for advanced lung cancer

  This study is testing if adding a new vaccine to standard lung cancer treatment can help people with advanced non-small cell lung cancer live longer without their disease getting worse.

  Recruiting Phase 2 Vestre Viken Hospital Trust · Drammen, Akershus · NCT05344209

• Using patient-derived tumoroids to predict response to immunotherapy in lung cancer

  This study is testing if lab-grown mini tumors from lung cancer patients can help doctors figure out who will benefit from a new type of immune therapy.

  Recruiting at 2 sites University of Kansas Medical Center · Fairway, Kansas and 1 other locations · NCT05332925

• Adding chemotherapy for patients with specific lung cancer mutations not responding to initial treatment

  This study is testing if adding chemotherapy to osimertinib can help patients with specific lung cancer mutations who aren't improving after starting osimertinib treatment.

  Recruiting at 16 sites Phase 2 Goethe University · Berlin and 15 other locations · NCT05281406

• Primary tumor removal after EGFR inhibitor in stage IV NSCLC

  This trial tests whether removing the main lung tumor after starting afatinib can help people with stage IV NSCLC that have an EGFR mutation.

  Recruiting at 2 sites Phase 2 National Taiwan University Hospital · Taipei and 1 other locations · NCT05215548

• Combining Atezolizumab and Pirfenidone for Advanced Lung Cancer

  This study is testing if adding pirfenidone to atezolizumab can help people with advanced lung cancer who have already been treated feel better and fight their cancer more effectively.

  Recruiting Phase 1/2 University of Kansas Medical Center · Fairway, Kansas and 1 other locations · NCT04467723

• Pemetrexed and carboplatin, with or without anlotinib, for advanced non-squamous NSCLC after osimertinib

  This trial tests whether adding anlotinib to pemetrexed plus carboplatin helps people with advanced non-squamous NSCLC whose cancer progressed on osimertinib.

  Recruiting Phase 2 Fudan University · Shenzhen, shenzhen · NCT04136535

Related topics

Quick answers

How many NSCLC Stage IV clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in China (7 trials), United States (5 trials), Germany (1 trial), Canada (1 trial), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 9, Phase 1/2: 3, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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