Condition

Muscle Invasive Bladder Urothelial Carcinoma clinical trials and research

• 9Clinical trials
• 1New in 30 days
• 3Countries

Newest Muscle Invasive Bladder Urothelial Carcinoma clinical trials

All recruiting trials (9)

• Bladder cancer: test a biomarker-guided plan after neoadjuvant therapy

  This phase 2 study tests a biomarker- and response-guided plan to preserve the bladder in patients with muscle-invasive bladder cancer after neoadjuvant therapy.

  Recruiting Phase 2 Fox Chase Cancer Center · Philadelphia, Pennsylvania · NCT07908979

• ctDNA-based monitoring in muscle-invasive bladder cancer

  This study tests whether a blood-based ctDNA test can flag residual or returning disease in adults with muscle-invasive bladder cancer undergoing standard treatments.

  Recruiting OHSU Knight Cancer Institute · Portland, Oregon · NCT07726602

• Shorter-course versus standard-course radiation with chemotherapy for muscle-invasive bladder cancer

  This trial tests whether a much shorter course of radiation plus standard chemotherapy works as well as the usual shorter radiation schedule for people with muscle-invasive bladder cancer who are pursuing bladder-preserving treatment.

  Recruiting at 247 sites Phase 3 NRG Oncology · Fairbanks, Alaska and 258 other locations · NCT07097142

• Immunotherapy plus radiation to avoid bladder removal after chemo for muscle-invasive bladder cancer

  This phase II test gives pembrolizumab with radiation after chemotherapy to try to help people with muscle-invasive bladder cancer keep their bladders instead of having them removed.

  Recruiting at 171 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 181 other locations · NCT07061964

• Combination treatment for muscle-invasive bladder cancer

  This study is testing a new combination of two medications to see if they can help people with muscle-invasive bladder cancer avoid surgery and improve their treatment outcomes.

  Recruiting at 5 sites Phase 2 Hoosier Cancer Research Network · Duarte, California and 4 other locations · NCT06809140

• Collecting samples from patients with certain types of cancer to improve detection and treatment.

  This study is collecting blood and tissue samples from patients with certain types of cancer to see if it can help improve how we detect cancer and understand the risk of it coming back.

  Recruiting at 47 sites Paradigm Health · Birmingham, Alabama and 46 other locations · NCT06605404

• Improving tumor detection before bladder cancer surgery

  This study is testing a new combination of tests to see if they can accurately find leftover tumors in bladder cancer patients before they have surgery.

  Recruiting at 2 sites Fox Chase Cancer Center · Omaha, Nebraska and 1 other locations · NCT06396533

• Observing quality of life in patients after bladder cancer surgery

  This study looks at how bladder cancer surgery affects the quality of life for patients over about 10 years by checking in with them each year.

  Recruiting IRCCS San Raffaele · Milan, MI · NCT06170177

• Using blood tests to guide immunotherapy after bladder cancer surgery

  This study is testing if blood tests can help doctors find out which bladder cancer patients need extra treatment after surgery and if combining two immunotherapy drugs works better than just one.

  Recruiting at 458 sites Phase 2/3 National Cancer Institute (NCI) · Phoenix, Arizona and 504 other locations · NCT05987241

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Quick answers

How many Muscle Invasive Bladder Urothelial Carcinoma clinical trials are recruiting right now?

9, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (8 trials), Canada (2 trials), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 2/3: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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