Condition

Chronic Myeloid Leukemia clinical trials and research

• 28Clinical trials
• 8NIH research projects
• 32Countries

Newest Chronic Myeloid Leukemia clinical trials

All recruiting trials (28)

• Dasatinib plus ropeginterferon for newly diagnosed chronic myeloid leukemia in chronic phase

  This study tests whether the drug combination dasatinib and ropeginterferon can help control chronic myeloid leukemia in adults with newly diagnosed disease.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT07269470

• Prophylactic DLI-X to Prevent Leukemia Relapse After Transplant

  This first-in-human trial tests a prophylactic DLI-X approach to see if it can prevent relapse after matched sibling or haploidentical stem cell transplant in patients with acute leukemias and related blood disorders.

  Recruiting Phase 1 University of Arizona · Tucson, Arizona · NCT07254793

• Optimizing post-transplant bendamustine plus cyclophosphamide for high‑risk myeloid cancers with a partially mismatched donor

  This trial tests whether giving bendamustine plus cyclophosphamide after transplant (with possible abatacept or ruxolitinib) can reduce dangerous cytokine release and graft‑versus‑host disease for people with high‑risk myeloid malignancies who have a partially HLA‑mismatched donor.

  Recruiting Phase 2 St. Petersburg State Pavlov Medical University · Saint Petersburg · NCT07238712

• CBX-250 for relapsed or refractory myeloid leukemias.

  This will try CBX-250, a new injectable medicine, in people aged 12 and older with relapsed or refractory AML, high-risk MDS, CMML, or CML to see if it can control disease with tolerable side effects.

  Recruiting at 11 sites Phase 1 Crossbow Therapeutics, Inc. · Duarte, California and 10 other locations · NCT06994676

• Olverembatinib monotherapy for adults with newly diagnosed chronic-phase CML

  We are testing whether olverembatinib can control disease and produce deep molecular responses in adults newly diagnosed with chronic-phase CML.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06817720

• Using Sorafenib to Prevent Relapse After Stem Cell Transplantation

  This study is testing if the drug sorafenib can help prevent relapse in patients with high-risk blood cancers after they receive a stem cell transplant.

  Recruiting Phase 2 St. Petersburg State Pavlov Medical University · Saint Petersburg · NCT06532084

• Vitamin A and D supplementation for patients undergoing allogeneic hematopoietic transplantation

  This study is testing if giving high doses of vitamins A and D before a stem cell transplant can help patients with certain blood cancers have fewer complications like infections and graft-versus-host disease.

  Recruiting Phase 2 St. Petersburg State Pavlov Medical University · Saint Petersburg · NCT06508099

• Evaluating TGRX-678 for patients with Chronic Myelogenous Leukemia

  This study is testing a new drug called TGRX-678 to see if it can help people with Chronic Myelogenous Leukemia who haven’t responded to other treatments.

  Recruiting Phase 2 Shenzhen TargetRx Co., Ltd. · Beijing, Beijing Municipality · NCT06453902

• Treatment of Chronic Myeloid Leukemia with Olverembatinib

  This study is testing if a new drug called olverembatinib can help people with chronic myeloid leukemia feel better compared to an existing treatment, and it looks at two groups of patients based on a specific genetic mutation.

  Recruiting at 135 sites Phase 3 Ascentage Pharma Group Inc. · Birmingham, Alabama and 162 other locations · NCT06423911

• Potential of asciminib in early chronic‑phase CML

  This trial will see if asciminib alone, or asciminib plus nilotinib, helps adults newly diagnosed with chronic‑phase, BCR‑ABL–positive CML reach deep molecular responses and remain off treatment.

  Recruiting at 11 sites Phase 2 Gruppo Italiano Malattie EMatologiche dell'Adulto · Barcelona and 10 other locations · NCT06409936

• Using Darzalex Faspro to lower antibody levels before stem cell transplant

  This study is testing if a new treatment called Darzalex Faspro can help lower harmful antibodies in adults so they can safely receive a stem cell transplant for blood cancers.

  Recruiting Early Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06398457

• Third-generation TKI combined with azacitidine and a Bcl-2 inhibitor for CML in myeloid blast phase

  This study will test whether adding a third-generation TKI to azacitidine and a Bcl-2 inhibitor helps adults with Philadelphia chromosome–positive chronic myeloid leukemia in myeloid blast phase.

  Recruiting at 8 sites Peking University People's Hospital · Beijing, Beijing Municipality and 14 other locations · NCT06390306

• Restoring gut bacteria before stem cell transplant for blood cancer patients

  This study is testing if restoring gut bacteria with a special treatment before stem cell transplants can help blood cancer patients have better health and treatment outcomes.

  Recruiting at 6 sites Phase 2 Imperial College London · Birmingham, England and 7 other locations · NCT06355583

• Evaluating asciminib for newly diagnosed chronic myeloid leukemia patients

  This study is testing a new drug called asciminib to see if it helps people with newly diagnosed chronic myeloid leukemia feel better and achieve a good response to treatment after a year.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06236724

• Examining how personality affects medication adherence in chronic myeloid leukemia patients

  This study is trying to see how different personality traits affect whether people with chronic myeloid leukemia stick to their medication plan.

  Recruiting University of California, Irvine · Orange, California · NCT06229860

• Evaluating TERN-701 for Chronic Myeloid Leukemia

  This study is testing a new drug called TERN-701 to see if it can safely help people with chronic myeloid leukemia who have already been treated.

  Recruiting at 48 sites Phase 1/2 Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) · Birmingham, Alabama and 53 other locations · NCT06163430

• Observational study of Asciminib in patients with Chronic Myeloid Leukemia

  This study is looking at how well Asciminib works and how safe it is for adults with Chronic Myeloid Leukemia in Korea who are using this medication as prescribed by their doctors.

  Recruiting at 17 sites Novartis · Wŏnju, Gangwon-do and 16 other locations · NCT05943522

• Depleting specific immune cells in stem cell transplants for blood cancers

  This study is testing if removing certain immune cells during stem cell transplants can help children and young adults with blood cancers have better outcomes and fewer complications.

  Recruiting Phase 2 University of Florida · Gainesville, Florida · NCT05800210

• Collecting blood samples to evaluate tests for early cancer detection

  This study is collecting blood and tissue samples from people with and without cancer to see if new tests can help detect cancer earlier.

  Recruiting at 619 sites Alliance for Clinical Trials in Oncology · Anchorage, Alaska and 750 other locations · NCT05334069

• Evaluating ELVN-001 for treating Chronic Myeloid Leukemia

  This study is testing a new treatment called ELVN-001 for people with chronic myeloid leukemia who haven't responded well to current therapies, to see if it can help them better.

  Recruiting at 38 sites Phase 1 Enliven Therapeutics · New York, New York and 44 other locations · NCT05304377

• Comparing the effectiveness of generic Imatinib to Glivec in treating Chronic Myeloid Leukemia

  This study is testing if a generic version of Imatinib works as well as the brand name Glivec for treating newly diagnosed adults with Chronic Myeloid Leukemia.

  Recruiting at 2 sites Hikma Pharmaceuticals LLC · Cairo and 3 other locations · NCT05282108

• Understanding Drug Interactions in Chronic Myeloid Leukemia Treatment

  This study is testing how different treatments work together for people with Chronic Myeloid Leukemia who are taking Tyrosine Kinase Inhibitors to see if adjusting their medications can help them do better.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne · NCT05130138

• Registry for patients with Chronic Myeloid Leukemia who stop treatment

  This study is looking to see if patients with Chronic Myeloid Leukemia can safely stop their medication and stay healthy without it.

  Recruiting University of Turin, Italy · Turin · NCT04769947

• Evaluating HQP1351 for patients with resistant leukemia

  This study is testing a new drug called HQP1351 to see if it can help patients with resistant chronic myeloid leukemia or Philadelphia positive acute lymphoblastic leukemia feel better and respond to treatment.

  Recruiting at 9 sites Phase 1 Ascentage Pharma Group Inc. · Birmingham, Alabama and 8 other locations · NCT04260022

• Expanded/activated gamma delta T-cell infusions after haploidentical stem cell transplant with post-transplant cyclophosphamide.

  This tests whether infusing expanded/activated gamma delta T cells after a partially matched (haploidentical) stem cell transplant with post-transplant cyclophosphamide helps control leukemia and reduce graft-versus-host disease in adults.

  Recruiting at 2 sites Phase 1 University of Kansas Medical Center · Westwood, Kansas and 1 other locations · NCT03533816

• HA-1 TCR T cell therapy for leukemia that returned or didn't respond after a donor stem cell transplant

  This Phase 1 study will test whether giving specially engineered donor T cells called HA-1 TCR T cells is safe and what dose works for people whose acute leukemia came back or didn't respond after a donor stem cell transplant.

  Recruiting Phase 1 Fred Hutchinson Cancer Center · Seattle, Washington · NCT03326921

• Combining selumetinib and azacitidine for high-risk chronic blood cancers

  This study is testing a new combination of two drugs, selumetinib and azacitidine, to see if it can help people with high-risk chronic blood cancers like chronic myeloid leukemia and myelofibrosis.

  Recruiting Phase 1 University of Chicago · Chicago, Illinois · NCT03326310

• International study on Chronic Myeloid Leukemia in children

  This study looks at children and teens with Chronic Myeloid Leukemia to learn more about their treatment outcomes and side effects.

  Recruiting at 17 sites Poitiers University Hospital · North Adelaide, South Australia and 19 other locations · NCT01281735

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Chronic myeloid leukemia: how T cells and leukemia stem cells interact during treatment

  This NIH grant explores how immune cells and stubborn leukemia stem cells interact during therapy to better predict if patients can stay off treatment.

  NIH research Northwestern University · Chicago, United States · NIH-11418370

• Targeting DYRK2 to kill leukemia stem cells in CML

  Aims to find ways to remove leukemia stem cells in chronic myeloid leukemia by boosting a protein (DYRK2) that can halt their growth.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11323889

• Why chronic myeloid leukemia sometimes resists treatment and how to improve TKI care

  This project looks at why some people with chronic myeloid leukemia respond differently to tyrosine kinase inhibitor drugs and aims to help more patients get deeper, longer-lasting remissions.

  NIH research University of California-Irvine · Irvine, United States · NIH-11306059

• Targeting a specific protein to eliminate leukemia stem cells in chronic myeloid leukemia.

  This study is looking at a new way to help people with chronic myeloid leukemia (CML) by focusing on a protein called DYRK2, which could help make leukemia stem cells less likely to survive, so patients might be able to stop their current treatments without their cancer coming back.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11109689

• Understanding how some patients with chronic myeloid leukemia can remain healthy without treatment

  This study is looking into why some people with chronic myeloid leukemia can stay healthy without taking their medication, using mice to find out what helps them maintain remission, which could lead to better ways to manage the condition and lessen the need for long-term treatment.

  NIH research University of California-Irvine · Irvine, United States · NIH-11078332

• Improving treatment for chronic myeloid leukemia with targeted therapies

  This study is looking for ways to help people with chronic myeloid leukemia (CML) respond better to their main treatment, tyrosine kinase inhibitors (TKIs), especially during the first year after they are diagnosed, so that more patients can achieve a lasting remission and possibly a cure.

  NIH research University of California-Irvine · Irvine, United States · NIH-11016818

• Targeting a specific protein to treat chronic myeloid leukemia

  This study is testing a new small protein that could help stop a key protein linked to chronic myeloid leukemia from working against you, and if it works, it might offer a fresh treatment option for patients like you.

  NIH research University of Utah · Salt Lake City, United States · NIH-11001839

• Understanding financial challenges faced by rural patients with Chronic Myeloid Leukemia

  This study is looking at how money struggles affect the health and well-being of people with Chronic Myeloid Leukemia living in rural Southeast areas, and it aims to find ways to help improve their situation.

  NIH research Emory University · Atlanta, United States · NIH-10913349

Related topics

Quick answers

How many Chronic Myeloid Leukemia clinical trials are recruiting right now?

28, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 32 countries. The most sites are in United States (16 trials), France (5 trials), Spain (5 trials), Russia (4 trials), Australia (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 10, Phase 1: 7, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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