Condition

Squamous Cell Carcinoma of Head and Neck clinical trials and research

• 33Clinical trials
• 1New in 30 days
• 27Countries

Newest Squamous Cell Carcinoma of Head and Neck clinical trials

All recruiting trials (33)

• TMV vaccine alone or with toripalimab for recurrent head and neck cancer

  This study tests a personalized TMV vaccine, alone and with toripalimab, in adults whose head and neck cancer has returned and is planning salvage surgery.

  Recruiting Phase 1 Metaclipse Therapeutics Corporation · Houston, Texas · NCT07898124

• Iparomlimab plus tuvonralimab, with or without chemotherapy, for second-line and later recurrent or metastatic head and neck squamous cell carcinoma

  This will try whether combining two antibodies, iparomlimab and tuvonralimab, with or without chemotherapy helps people with recurrent or metastatic head and neck squamous cell carcinoma whose cancer progressed after at least one systemic treatment.

  Recruiting The Second Affiliated Hospital of Hainan Medical University · Haikou, Hainan · NCT07546383

• Cetuximab with PD-1 therapy plus chemotherapy vs PD-1 therapy with chemotherapy for recurrent/metastatic head and neck cancer

  This trial tests whether adding cetuximab to a PD-1 inhibitor plus chemotherapy helps people with recurrent or metastatic head and neck squamous cell cancer who aren’t candidates for curative treatment.

  Recruiting Phase 3 Fudan University · Shanghai, Shanghai Municipality and 1 other locations · NCT07509099

• Neoadjuvant CADI-05 with pembrolizumab for resectable locally advanced head and neck squamous cell carcinoma

  This will test whether adding weekly CADI-05 skin injections to pembrolizumab before surgery helps adults with resectable locally advanced head and neck squamous cell cancer.

  Recruiting at 2 sites Phase 1 Fox Chase Cancer Center · Philadelphia, Pennsylvania and 1 other locations · NCT07455032

• 5-Fluorouracil Response and Optimization (FROST)

  This trial will test two different dosing schedules of 5‑fluorouracil as second-line-or-later treatment for people with recurrent or metastatic head and neck squamous cell carcinoma who have already had platinum and PD‑1 inhibitor therapy.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT07419464

• Amivantamab added to pembrolizumab and platinum chemotherapy versus pembrolizumab with platinum/5‑FU for recurrent/metastatic head and neck squamous cell carcinoma

  This trial will see if adding amivantamab to pembrolizumab and platinum‑based chemotherapy helps adults with recurrent or metastatic head and neck squamous cell carcinoma who have not yet had systemic treatment in the metastatic setting.

  Recruiting at 205 sites Phase 3 Janssen Research & Development, LLC · Chandler, Arizona and 204 other locations · NCT07276399

• Intratumoral JNJ-90301900 combined with chemoradiation for locally advanced head and neck squamous cell carcinoma

  This phase 1b test will try injecting JNJ-90301900 directly into tumors alongside standard cisplatin chemotherapy and radiation to see if it is safe and helps people with locally advanced head and neck squamous cell carcinoma.

  Recruiting at 24 sites Phase 1 Johnson & Johnson Enterprise Innovation Inc. · Birmingham, Alabama and 24 other locations · NCT07219212

• TH9619 for advanced solid tumors (Phase 1/2)

  This trial will try different doses of TH9619 in adults with advanced solid tumors (including colorectal, head and neck, non-small cell lung, and gastroesophageal cancers) to find a recommended dose and check safety.

  Recruiting at 4 sites Phase 1/2 OneCarbon · Villejuif and 3 other locations · NCT07151040

• Sacituzumab govitecan plus cetuximab for recurrent or metastatic head and neck squamous cell cancer

  This trial will test whether combining sacituzumab govitecan with cetuximab works and is safe for people whose head and neck squamous cell cancer has returned or spread after prior immunotherapy.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07063212

• Neoadjuvant PD-L1 antibody plus chemotherapy for locally advanced head and neck squamous cell carcinoma

  This trial will try giving the PD-L1 antibody adebrelimab with docetaxel and cisplatin before surgery for people with stage III–IVB head and neck squamous cell carcinoma to see if it shrinks tumors and improves surgical outcomes.

  Recruiting Phase 2 Shandong Tumor Hospital · Jinan, Shandong · NCT07055841

• Blood test to detect cancer recurrence in head and neck patients

  This study is testing a personalized blood test to see if it can help predict if head and neck cancer will come back after treatment.

  Recruiting Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT06744296

• Testing blood samples for cancer DNA in head and neck cancer patients

  This study is testing if checking blood samples for cancer DNA can help predict if head and neck cancer patients will have a relapse after their treatment.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06606028

• Milaberon for treating advanced solid tumors

  This study is testing if a higher dose of mirabegron can help people with advanced solid tumors feel better while keeping an eye on any side effects.

  Recruiting Phase 2 Zhejiang Provincial People's Hospital · Hangzhou, Zhejiang · NCT06534762

• Testing DM005 for advanced solid tumors

  This study is testing a new treatment called DM005 to see if it can help people with advanced solid tumors feel better and improve their health.

  Recruiting at 6 sites Phase 1/2 Doma Biopharmaceutical（Suzhou）Co., Ltd. · Detroit, Michigan and 5 other locations · NCT06515990

• Cisplatin chemotherapy with radiotherapy for high-risk head and neck cancer after surgery

  This study tests whether giving two rounds of cisplatin chemotherapy along with radiation after surgery can help people with high-risk head and neck cancer live longer without their cancer coming back compared to three rounds of chemotherapy.

  Recruiting Phase 3 Sun Yat-sen University · Guangzhou, Guangdong and 4 other locations · NCT06492460

• Effects of Delayed Elective Radiotherapy on Head and Neck Cancer Biomarkers

  This study is testing whether starting radiation therapy later helps people with newly diagnosed head and neck cancer by looking at changes in their tumors and immune markers during treatment.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06487403

• Testing amivantamab for recurrent or metastatic head and neck cancer

  This study is testing if a new drug called amivantamab, alone or with other treatments, can help people with recurrent or metastatic head and neck cancer feel better.

  Recruiting at 51 sites Phase 1/2 Janssen Research & Development, LLC · La Jolla, California and 55 other locations · NCT06385080

• Testing UCB4594 for advanced cancer treatment

  This study is testing a new drug called UCB4594 to see if it can help treat advanced cancer by targeting a specific protein on cancer cells.

  Recruiting at 3 sites Phase 1/2 Cancer Research UK · London and 3 other locations · NCT06380816

• Using an app to track nutrition in head and neck cancer patients during treatment

  This study is testing whether using an app to track nutrition can help head and neck cancer patients maintain a healthy diet during and after their treatment.

  Recruiting University of Erlangen-Nürnberg Medical School · Erlangen, Bavaria · NCT06367257

• Testing MGC026 in patients with advanced solid tumors

  This study is testing a new treatment called MGC026 to see if it can help adults with advanced solid tumors that can't be removed or have spread to other parts of the body.

  Recruiting at 12 sites Phase 1 MacroGenics · Los Angeles, California and 11 other locations · NCT06242470

• Treatment for advanced laryngeal and hypopharyngeal cancer using chemotherapy and immunotherapy

  This study is testing if adding an immune therapy to chemotherapy can help people with advanced throat cancer keep their voice box while improving their chances of survival.

  Recruiting at 5 sites Phase 2 University of Leipzig · Mannheim, Baden-Würtemberg and 8 other locations · NCT06137378

• Exploring MRI and Biomarkers in Head and Neck Cancer Treatment

  This study is testing how MRI scans and certain biological markers can help doctors understand how well treatments are working for people with newly diagnosed head and neck cancer.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06085781

• Therapeutic vaccine to reduce cancer recurrence in head and neck cancer patients

  This study is testing a new vaccine to see if it can help prevent cancer from coming back in adults who have finished treatment for head and neck cancer.

  Recruiting at 6 sites Phase 2 University of Arkansas · Fayetteville, Arkansas and 5 other locations · NCT05952934

• Personalizing cancer therapy by measuring immune suppression

  This study is testing whether measuring certain immune cells in cancer patients can help tailor their treatments and understand how feelings of isolation might affect their immune system.

  Recruiting Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Milan · NCT05621837

• Implantable microdevice drug screening for salivary and head and neck cancers

  This will test whether a tiny implantable microdevice can safely and quickly deliver and screen multiple cancer drugs inside salivary gland and other head and neck tumors in patients scheduled for surgical removal.

  Recruiting at 2 sites Early Phase 1 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT05553782

• Combining 5-Azacytidine and Nivolumab for HPV-Associated Head and Neck Cancer

  This study is testing if combining a chemotherapy drug and an immunotherapy can help people with HPV-related head and neck cancer do better than using either treatment alone.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT05317000

• Treatment for resectable melanoma and head and neck cancer using immune therapies

  This study is testing a new combination of immune therapies to see if they can help people with resectable melanoma and head and neck cancer feel better and improve their treatment outcomes before and after surgery.

  Recruiting at 15 sites Phase 2 IO Biotech · New Haven, Connecticut and 14 other locations · NCT05280314

• Testing BMS-986340 alone and with other treatments for advanced solid tumors

  This study is testing a new treatment called BMS-986340, both on its own and with other drugs, to see how safe it is for people with advanced solid tumors.

  Recruiting at 39 sites Phase 1/2 Bristol-Myers Squibb · Clovis, California and 46 other locations · NCT04895709

• Combining radiotherapy and pembrolizumab for metastatic head and neck cancers

  This study is testing if combining radiation therapy with pembrolizumab can help people with newly diagnosed metastatic head and neck cancer do better than standard treatments.

  Recruiting at 20 sites Phase 3 Unicancer · Avignon and 25 other locations · NCT04747054

• Reducing radiation for head and neck cancer treatment

  This study is testing if using a special mapping technique can help reduce the amount of radiation needed for patients with head and neck cancer while still effectively treating their disease.

  Recruiting at 10 sites Universitaire Ziekenhuizen KU Leuven · Genk, Limburg and 9 other locations · NCT04688528

• Optimized early care for head and neck squamous cell carcinoma

  This program tries extra nutrition and supportive care to help adults with localized head and neck squamous cell carcinoma complete post‑operative cisplatin chemoradiation.

  Recruiting at 6 sites Centre Henri Becquerel · Amiens and 6 other locations · NCT04528420

• Investigating BCA101 for advanced solid tumors driven by EGFR

  This study is testing a new treatment called BCA101 to see if it can help people with advanced solid tumors that are driven by EGFR, especially those who haven't responded to other therapies.

  Recruiting at 21 sites Phase 1 Bicara Therapeutics · La Jolla, California and 20 other locations · NCT04429542

• Testing a new drug for advanced solid tumors

  This study is testing a new drug called sigvotatug vedotin to see if it can safely help people with advanced solid tumors, both on its own and with other treatments.

  Recruiting at 145 sites Phase 1 Seagen Inc. · Anchorage, Alaska and 157 other locations · NCT04389632

Related topics

Quick answers

How many Squamous Cell Carcinoma of Head and Neck clinical trials are recruiting right now?

33, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in United States (18 trials), France (8 trials), Spain (7 trials), China (7 trials), Australia (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 8, Phase 1: 6, Phase 1/2: 5, Phase 3: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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